Effect of high-fat diet on cognitive impairment in triple-transgenic mice model of Alzheimer's disease

SK Sah, C Lee, JH Jang, GH Park - Biochemical and biophysical research …, 2017 - Elsevier
… In this study, the effect of HFD on memory impairment at the pre-ageing stage and its … High-fat
diet-induced memory impairment in triple-transgenic Alzheimer's disease (3xTgAD) mice is …

[HTML][HTML] Contributions of a high-fat diet to Alzheimer's disease-related decline: a longitudinal behavioural and structural neuroimaging study in mouse models

CPE Rollins, D Gallino, V Kong, G Ayranci… - NeuroImage: Clinical, 2019 - Elsevier
… Adolescent high-fat diet-induced obesity altered adult brain … and behaviour of the triple
transgenic mouse model of AD (3xTg) … Status as a 3xTg AD-like mouse has no significant effect on …

High-fat diet exacerbates cognitive decline in mouse models of Alzheimer's disease and mixed dementia in a sex-dependent manner

OJ Gannon, LS Robison, AE Salinero… - Journal of …, 2022 - Springer
… MxD, we found that diet-induced obesity with prediabetes led … While episodic-like memory
deficits were observed in AD … Additionally, HF diet can accelerate AD pathology in 3xTg-AD

[PDF][PDF] Exercise Attenuates High-Fat Dietinduced Disease Progression in 3xTg-AD Mice

D Kim, J Cho, I Lee, Y Jin, H Kang - Medicine & Science in Sports …, 2017 - researchgate.net
High-fat diet-induced memory impairment in triple transgenic Alzheimer"s disease (3xTgAD)
mice … increase in brain AA and improves memory in an animal model of Alzheimer disease. …

Role of sex and high-fat diet in metabolic and hypothalamic disturbances in the 3xTg-AD mouse model of Alzheimer's disease

LS Robison, OJ Gannon, MA Thomas… - Journal of …, 2020 - Springer
… Overall, our current findings provide additional evidence for increased susceptibility to
diet-induced metabolic dysregulation in the presence of AD pathology, which has been reported …

Tetrahydrobiopterin improves recognition memory in the triple-transgenic mouse model of Alzheimer's disease, without altering amyloid-β and tau pathologies

H Fanet, M Tournissac, M Leclerc… - … of Alzheimer's …, 2021 - content.iospress.com
… BH4 administration could ameliorate memory impairment in 3xTg-AD mice owing to …
triple-transgenic mice (3xTg-AD) mice were fed from the age of 6 months a control (CD) or a high-fat

The effect of dietary fat consumption on Alzheimer's disease pathogenesis in mouse models

A Amelianchik, L Sweetland-Martin… - Translational Psychiatry, 2022 - nature.com
… to conflicting reports on how diet-induced obesity affects AD-related … -fed 3xTgAD mice no
longer showed memory impairment … tau pathology in a triple transgenic mouse model of AD, …

[PDF][PDF] HighFat Diet Modulates Hepatic Amyloid β and Cerebrosterol Metabolism in the Triple Transgenic Mouse Model of Alzheimer's Disease

CR Bosoi, M Vandal, M Tournissac… - Hepatology …, 2021 - Wiley Online Library
… We show that the AD triple transgenic mouse model (3xTg-AD… same or similar tests
probing for memory loss is an essential … in diet-induced obese mice. Diabetologia 2016;59:592-603. …

High-fat diet negatively affects brain markers, cognitive behaviors, and noncognitive behaviors in the rTg4510 tau mouse model

SLP Lippi, RE Barkey, MN Rodriguez - Physiology & Behavior, 2023 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative disorder … in those with not only mild
cognitive impairment (MCI), but also … ) and 3xTg-AD female mice, those given a high-fat diet had …

A high fat/cholesterol diet recapitulates some Alzheimer's disease-like features in mice: focus on hippocampal mitochondrial dysfunction

G Mancini, C Dias, CF Lourenco… - … of Alzheimer's …, 2021 - content.iospress.com
… has been observed in patients suffering of mild cognitive impairment (MCI), suggesting that
… using the triple transgenic mouse model of Alzheimer’s disease (3xTgAD) harboring AD-…