The histone acetyltransferase p300 inhibitor C646 reduces pro-inflammatory gene expression and inhibits histone deacetylases

T Van Den Bosch, A Boichenko, NGJ Leus… - Biochemical …, 2016 - Elsevier
… affect the NF-κB pathway; an important pathway in inflammatory … Therefore, we hypothesized
that via regulation of the NF-κB … of (NF-κB mediated) inflammation, an NF-κB reporter gene …

Histone deacetylase 3 (HDAC 3) as emerging drug target in NF-κB-mediated inflammation

NGJ Leus, MRH Zwinderman, FJ Dekker - Current opinion in chemical …, 2016 - Elsevier
histones, HDACs also target non-histone proteins. The nuclear factor κB (NF-κB) pathway
is an important regulator … by histone acetyltransferases (HATs) and histone deacetylases (…

Histone methylation and acetylation in macrophages as a mechanism for regulation of inflammatory responses

MG Daskalaki, C Tsatsanis… - Journal of cellular …, 2018 - Wiley Online Library
… knowledge on the role of histone acetyltransferases (HATs), … to be important for
Interferon-regulatory factor 5 (Irf5) gene … to regulate inflammatory responses via regulation of …

[HTML][HTML] Activated histone acetyltransferase p300/CBP-related signalling pathways mediate up-regulation of NADPH oxidase, inflammation, and fibrosis in diabetic …

AG Lazar, ML Vlad, A Manea, M Simionescu… - Antioxidants, 2021 - mdpi.com
… Based on the important functions of the dysregulated histoneregulator of Nox expression,
ROS production, inflammation, and … of p300/CBP mediates the up-regulation of Nox subtypes, …

… alleviates lipopolysaccharide-induced inflammatory responses by down-regulation of NF-κB, NLRP3 signaling pathway, and activating histone acetylation in bovine …

L Jiang, J Wang, Z Liu, A Jiang, S Li, D Wu… - Frontiers in Veterinary …, 2020 - frontiersin.org
… modification that plays important role in the regulation of gene … cell membrane that mediate
activation of the NF-κB signaling … the action of histone acetyltransferase, which facilitates …

Stabilization of the histone acetyltransferase Tip60 by deubiquitinating enzyme USP7 stimulates the release of pro-inflammatory mediators in acute lung injury

J Wang, HY Li, ZB Su - Journal of Molecular Medicine, 2020 - Springer
… its regulation of corresponding cellular inflammatory responses, … inflammation and apoptosis
by inhibiting Tip60 and NF-κBInflammation exerts crucial effects on the progression of ALI […

Histone Acetyltransferase‐Dependent Pathways Mediate Upregulation of NADPH Oxidase 5 in Human Macrophages under Inflammatory Conditions: A Potential …

ML Vlad, SA Manea, AG Lazar, M Raicu… - Oxidative medicine …, 2019 - Wiley Online Library
… The mechanisms of Nox5 regulation are not entirely … the expression pattern of key histone
acetyltransferase subtypes (… an important role in cardiovascular pathology, including NF-κB, …

Epigenetic regulation of inflammatory signaling and inflammation-induced cancer

SYX Tan, J Zhang, WW Tee - Frontiers in Cell and Developmental …, 2022 - frontiersin.org
… and histone variants function in mediating inflammatory responses. … non-histone proteins
such as NF-κB, a key regulator of … An in vitro study illustrated that the histone acetyltransferase

Role of histone deacetylases in monocyte function in health and chronic inflammatory diseases

RM Tordera, M Cortés-Erice - Reviews of Physiology, Biochemistry and …, 2021 - Springer
… process carried out by histone acetyltransferases (HAT) and histone deacetylases (HDAC). …
positive regulator of the inflammatory response induced by the NF-κB pathway playing a key

Higher‐order chromatin regulation of inflammatory gene expression

JW Xu, S Ling, J Liu - Mediators of Inflammation, 2017 - Wiley Online Library
regulation, including the stimulus-responsive NF-κB. Dynamic changes in intra- and
interchromosomes are the key regulatory … p300 is a histone acetyltransferase that catalyzes …