… structural and functional characteristics of this enzyme subclass. PRMT4, which catalyzes
the asymmetric dimethylation of H3R17 and H3R26, is a transcription co-activator of nuclear …

… histone modifications and their associated enzymes. One current viewpoint, based largely
on correlative evidence, posits that histone modifications … ligase with specificity for H2AK119 (…

… Herein, we highlight the structural and functional consequences of histone modifying enzymes.
Because of their ubiquitous role in various disease states, we also describe several drug …

… enzymes and in some cases the modified amino acid. Probe-specificity is commonly mediated
by integration of histone-… In several cases, linkers that mediate specificity for an isoform or …

… the interaction between histones and DNA. The acetylated histone modification affects the
… Therefore, the improvement of HDAC isoform specificity is likely one of the most pressing …

… The HAT isoenzymes have various substrate specificities for histone or non-histone proteins…
all four histone subtypes (histone H2A, H2B, H3, and H4), but KAT6A acetylates only histone …

… Histone modifying enzymes are therefore potential drug targets for these diseases [3, 4]. Small
molecule inhibitors of histone … Histone H3 and H4 lysine substrate-specificity of HMTs and …

… , proline isomerization, and ubiquitination by specific modifying enzymes. But other … activities
operate on a genome-wide basis with minimal specificity for particular chromosomal regions…

… specificity for zCD1 was somewhat more relaxed. We describe the structural basis for the strict
substrate specificity … illuminated the structural basis of substrate specificity and catalysis for …

… between histone modifications and allergic phenotypes. Inhibitors of histone-modifying enzymes
may … H4ac levels at the glucocorticoid response element upstream of the dual specificity …