“Reframing” dopamine signaling at the intersection of glial networks in the aged Parkinsonian brain as innate Nrf2/Wnt driver: Therapeutical implications
B Marchetti, C Giachino, C Tirolo, MF Serapide - Aging Cell, 2022 - Wiley Online Library
… and the second most common neurodegenerative disease (ND) … One critical feature of
astrocytes is to protect the vulnerable … Indeed, within this scenario, DA emerges as a pivotal …
astrocytes is to protect the vulnerable … Indeed, within this scenario, DA emerges as a pivotal …
[HTML][HTML] Wnt signaling prevents the Aβ oligomer-induced mitochondrial permeability transition pore opening preserving mitochondrial structure in hippocampal …
MS Arrázola, E Ramos-Fernández, P Cisternas… - PLoS …, 2017 - journals.plos.org
… Alzheimer’s disease (AD) is a neurodegenerative disorder mainly … We proposed here to
study whether Wnt signaling protects … This scenario widens the range of candidates that could …
study whether Wnt signaling protects … This scenario widens the range of candidates that could …
Resveratrol protects SAMP8 brain under metabolic stress: focus on mitochondrial function and Wnt pathway
V Palomera-Avalos, C Griñán-Ferré… - Molecular …, 2017 - Springer
… in the cognitive and cellular pathways altered in SAMP8 … in neurodegeneration, and
resveratrol can offer therapeutic possibilities for preventive strategies in aging or neurodegenerative …
resveratrol can offer therapeutic possibilities for preventive strategies in aging or neurodegenerative …
[HTML][HTML] Mitochondria-Nucleus communication in neurodegenerative disease. Who talks first, who talks louder?
DI Savu, N Moisoi - Biochimica et Biophysica Acta (BBA)-Bioenergetics, 2022 - Elsevier
… neurodegenerative disease. Thus, we detail the transcriptional responses initiated by
mitochondrial dysfunction in order to protect … stress pathways initiated by DNA damage which …
mitochondrial dysfunction in order to protect … stress pathways initiated by DNA damage which …
[HTML][HTML] Wnt signaling and its impact on mitochondrial and cell cycle dynamics in pluripotent stem cells
ML Rasmussen, NA Ortolano, AI Romero-Morales… - Genes, 2018 - mdpi.com
… ] and have been linked to both neurodegenerative and neurodevelopmental diseases such
as … Perhaps constitutive activation of low levels of Wnt signal in HSCs could protect cells from …
as … Perhaps constitutive activation of low levels of Wnt signal in HSCs could protect cells from …
[HTML][HTML] Dysregulated Wnt signalling in the Alzheimer's brain
ND Aghaizu, H Jin, PJ Whiting - Brain Sciences, 2020 - mdpi.com
… ), an age-related neurodegenerative disorder that is the most … /out of the CNS and to protect
the CNS from peripheral insults [… of Wnt signalling dysregulation between these two scenarios…
the CNS from peripheral insults [… of Wnt signalling dysregulation between these two scenarios…
Molecular mechanisms of developmental pathways in neurological disorders: a pharmacological and therapeutic review
… severe neurodegeneration [11]. Similar to other embryonic … signalling pathway confers
some type of protection to the … of mitochondrial events such as mPTP opening, mitochondrial …
some type of protection to the … of mitochondrial events such as mPTP opening, mitochondrial …
Molecular basis of neurodegeneration: Lessons from Alzheimer's and Parkinson's diseases
JM Zolezzi, S Bastías-Candia… - Rec. Adv …, 2019 - books.google.com
… the mitochondria, suggests that the intracellular APP dynamics can also be part of the
pathological scenario … attenuates neuroinflammation and protects against neurodegeneration in a …
pathological scenario … attenuates neuroinflammation and protects against neurodegeneration in a …
Emerging roles of signal transduction pathways in neurodegenerative diseases. Hunting new possible therapeutic molecular targets
VR Lo Vasco - OBM Geriatrics, 2023 - iris.unimore.it
… discuss the main signal transduction pathways involved in neurodegenerative disorders. …
How the Wnt signaling pathway protects from neurodegeneration: The mitochondrial scenario. …
How the Wnt signaling pathway protects from neurodegeneration: The mitochondrial scenario. …
sFRP-mediated Wnt sequestration as a potential therapeutic target for Alzheimer's disease
… of sFRPs on neurodegeneration, their … mitochondrial permeability transition pore. It has
also been found that β-catenin independent Wnt signaling, through the Wnt5a ligand, protects …
also been found that β-catenin independent Wnt signaling, through the Wnt5a ligand, protects …