Reframing” dopamine signaling at the intersection of glial networks in the aged Parkinsonian brain as innate Nrf2/Wnt driver: Therapeutical implications

B Marchetti, C Giachino, C Tirolo, MF Serapide - Aging Cell, 2022 - Wiley Online Library
… and the second most common neurodegenerative disease (ND) … One critical feature of
astrocytes is to protect the vulnerable … Indeed, within this scenario, DA emerges as a pivotal …

[HTML][HTML] Wnt signaling prevents the Aβ oligomer-induced mitochondrial permeability transition pore opening preserving mitochondrial structure in hippocampal …

MS Arrázola, E Ramos-Fernández, P Cisternas… - PLoS …, 2017 - journals.plos.org
… Alzheimer’s disease (AD) is a neurodegenerative disorder mainly … We proposed here to
study whether Wnt signaling protects … This scenario widens the range of candidates that could …

Resveratrol protects SAMP8 brain under metabolic stress: focus on mitochondrial function and Wnt pathway

V Palomera-Avalos, C Griñán-Ferré… - Molecular …, 2017 - Springer
… in the cognitive and cellular pathways altered in SAMP8 … in neurodegeneration, and
resveratrol can offer therapeutic possibilities for preventive strategies in aging or neurodegenerative

[HTML][HTML] Mitochondria-Nucleus communication in neurodegenerative disease. Who talks first, who talks louder?

DI Savu, N Moisoi - Biochimica et Biophysica Acta (BBA)-Bioenergetics, 2022 - Elsevier
neurodegenerative disease. Thus, we detail the transcriptional responses initiated by
mitochondrial dysfunction in order to protect … stress pathways initiated by DNA damage which …

[HTML][HTML] Wnt signaling and its impact on mitochondrial and cell cycle dynamics in pluripotent stem cells

ML Rasmussen, NA Ortolano, AI Romero-Morales… - Genes, 2018 - mdpi.com
… ] and have been linked to both neurodegenerative and neurodevelopmental diseases such
as … Perhaps constitutive activation of low levels of Wnt signal in HSCs could protect cells from …

[HTML][HTML] Dysregulated Wnt signalling in the Alzheimer's brain

ND Aghaizu, H Jin, PJ Whiting - Brain Sciences, 2020 - mdpi.com
… ), an age-related neurodegenerative disorder that is the most … /out of the CNS and to protect
the CNS from peripheral insults [… of Wnt signalling dysregulation between these two scenarios

Molecular mechanisms of developmental pathways in neurological disorders: a pharmacological and therapeutic review

NK Jha, WC Chen, S Kumar, R Dubey… - Open …, 2022 - royalsocietypublishing.org
… severe neurodegeneration [11]. Similar to other embryonic … signalling pathway confers
some type of protection to the … of mitochondrial events such as mPTP opening, mitochondrial

Molecular basis of neurodegeneration: Lessons from Alzheimer's and Parkinson's diseases

JM Zolezzi, S Bastías-Candia… - Rec. Adv …, 2019 - books.google.com
… the mitochondria, suggests that the intracellular APP dynamics can also be part of the
pathological scenario … attenuates neuroinflammation and protects against neurodegeneration in a …

Emerging roles of signal transduction pathways in neurodegenerative diseases. Hunting new possible therapeutic molecular targets

VR Lo Vasco - OBM Geriatrics, 2023 - iris.unimore.it
… discuss the main signal transduction pathways involved in neurodegenerative disorders. …
How the Wnt signaling pathway protects from neurodegeneration: The mitochondrial scenario. …

sFRP-mediated Wnt sequestration as a potential therapeutic target for Alzheimer's disease

S Warrier, R Marimuthu, S Sekhar… - The international journal …, 2016 - Elsevier
… of sFRPs on neurodegeneration, their … mitochondrial permeability transition pore. It has
also been found that β-catenin independent Wnt signaling, through the Wnt5a ligand, protects