… are the opiates, including natural products such as morphine as well … pathways (such as
arrestin-mediated signaling pathways). … The modulation of neuropeptide signaling can occur via …

… Opiorphin (Gln–Arg–Phe–Ser–Arg) is a human endogenous … various pathways in the
mammalian body. For instance, … It displays a potent, naloxone-sensitive antinociceptive effect in …

… opiorphin family plays the role of a natural antinoceptive modulator of opioid-dependent
pathways by inhibiting two enkephalin-catabolizing ectoenzymes, human ectoaminopeptidase (…

… Specifically, their modulation may affect melanocortin four receptor … The levels of the
antinociceptive and inflammatory … Exploring the nature of this relationship might be interesting …

… detection, transmission and modulation of pain messages and … as a new pharmacological
pathway. Clinical studies should … an antinociceptive effect similar to that of morphine but lesser …

… A promising option is opiorphin, a pentapeptide that was first isolated from human saliva.
Opiorphin impairs the degradation of endogenous enkephalins by inhibiting a neutral …

… These results suggest that the modulation of protein contents of … natural social interaction
between mice. The molecular findings suggest that this effect is mediated through modulation …

… to the extraction of opiorphin in human saliva prior to its quantification by LC-MS/MS.
Opiorphin, a pentapeptide first isolated in 2006 from human saliva, is a natural enkephalin with a …

… on the biological activity of opiorphins and the molecular pathways regulated by PROL1 …
that opiorphin directly regulates vascular smooth muscle tone with dysregulated opiorphin …

l- to d-residue isomerization is a post-translational modification (PTM) present in neuropeptides,
peptide hormones, and peptide toxins from several animals. In most cases, the d-…