… for drugs interfering with other pathways involving adenosine, opiorphins, androgens
and the … ) and direct modulators of hemoglobin oxygen affinity, such as 5-hydroxymethylfurfural. …

… PTEN is a negative modulator of the PI3K pathway. … of human submaxillary gland
androgen-regulated protein 3A gene (SMR3A), which belong to a gene family encoding the …

… and specifically to the naturally occurring growth factors … opiorphin, a potent natural pain
killing substance, is also present in saliva; this endogenous compound, first isolated from human …

… OPRPN-derived opiorphin was reported to act as a potent … , which regulate signaling pathways
mediating cell proliferation, … of human opiorphin proteins for HNSCC after radiotherapy. …

… Human Opiorphin, a natural antinociceptive modulator of opioid-dependent pathways.
Proceedings of the National Academy of Sciences of the United States of America, 103(47): 17979…

… Opiorphin was first isolated from human saliva by investigators at the Pasteur Institute, and
… Opiorphin is predicted to work by stopping the normal breakup of enkephalins, natural pain-…

… The opiorphin signaling pathway is a recently recognized potential mediator of cavernosal
… Human Opiorphin, a natural antinociceptive modulator of opioiddependent pathways. Proc …

… to dopamine release in the mesolimbic pathway as the “Brain Reward … KB220 was used to
detoxify opioid-dependent patients … nergic function or its modulation concerning mental health …

… of NEP inhibitors in humans [25]. Apart from synthetic inhibitors, there are natural endogenous
NEP … AICD is formed alongside Aβ amyloid peptide in the amyloidogenic pathway, which …

… Human opiorphin (QRFSR) and rat sialorphin (QHNPR) are natural inhibitors of enkephalin
catabolism. Opiorphin was identified in human saliva and it showed beneficial effects in pain …