Pitx2c increases in atrial myocytes from chronic atrial fibrillation patients enhancing IKs and decreasing ICa,L
M Perez-Hernandez, M Matamoros… - Cardiovascular …, 2016 - academic.oup.com
… atrial action potential duration (APD) and refractoriness as a consequence of alterations in
the expression and function of L-type Ca 2+ … been obtained in mouse models. Therefore, this …
the expression and function of L-type Ca 2+ … been obtained in mouse models. Therefore, this …
[HTML][HTML] Towards Improved Human In Vitro Models for Cardiac Arrhythmia: Disease Mechanisms, Treatment, and Models of Atrial Fibrillation
C Cofiño-Fabres, R Passier, V Schwach - Biomedicines, 2023 - mdpi.com
… to normal sinus rhythm, (2) persistent AFib when episodes … of the atrial action potential,
characteristic of atrial remodeling [… Ca 2+ handling has been provided in animal models of AFib […
characteristic of atrial remodeling [… Ca 2+ handling has been provided in animal models of AFib […
[HTML][HTML] … I Antiarrhythmic Drug Effects on Pitx2-Induced Atrial Fibrillation: Insights from Populations of Electrophysiological Models of Human Atrial Cells and Tissues
… of in silico models calibrated to values of action potential (AP) … First, the initial population
of sinus rhythm (SR) models was … changes in atrial Ca 2+ handling due to AF itself [95]. …
of sinus rhythm (SR) models was … changes in atrial Ca 2+ handling due to AF itself [95]. …
[HTML][HTML] Atrial fibrillation dynamics and ionic block effects in six heterogeneous human 3D virtual atria with distinct repolarization dynamics
… to quantify how variability in action potential duration (APD) at … block using a set of virtual
whole-atria human models. Six … the six whole-atria models in sinus rhythm. These distributions …
whole-atria human models. Six … the six whole-atria models in sinus rhythm. These distributions …
Personalization of mathematical models of human atrial action potential
AV Pikunov, RA Syunyaev, V Steckmeister… - Smart Modelling For …, 2021 - Springer
… according to the diagnosis: sinus rhythm (SR), postoperative AF, paroxysmal AF, and chronic
AF (referred to … Intracellular Ca 2+ measurements were not considered in the present study. …
AF (referred to … Intracellular Ca 2+ measurements were not considered in the present study. …
Trigger-Specific Remodeling of KCa2 Potassium Channels in Models of Atrial Fibrillation
AK Rahm, D Gramlich, T Wieder… - Pharmacogenomics …, 2021 - Taylor & Francis
… contribute to cardiac action potential repolarization and are … Ca 2 channels in a porcine
atrial fibrillation (AF)/heart failure … of atrial burst pacing compared to sinus rhythm (SR) controls. …
atrial fibrillation (AF)/heart failure … of atrial burst pacing compared to sinus rhythm (SR) controls. …
[HTML][HTML] Mechanisms of action of the KCa2-negative modulator AP30663, a novel compound in development for treatment of atrial fibrillation in man
BH Bentzen, SH Bomholtz, R Simó-Vicens… - Frontiers in …, 2020 - frontiersin.org
… showed that K Ca 2 channels during sinus rhythm as well as … using a linear additive model,
where genotype was encoded … not result in an atrial action potential, whereas the second S2 …
where genotype was encoded … not result in an atrial action potential, whereas the second S2 …
Differential left-to-right atria gene expression ratio in human sinus rhythm and atrial fibrillation: Implications for arrhythmogenesis and thrombogenesis
… between the two groups was determined by linear modeling (controlled for false discovery
rate < 5%)… The difference in potassium currents may cause spatial gradients in action potential …
rate < 5%)… The difference in potassium currents may cause spatial gradients in action potential …
[HTML][HTML] In silico investigation of the mechanisms underlying atrial fibrillation due to impaired Pitx2
… We have demonstrated that shortened action potential … ATPase increases sarcoplasmic
reticulum Ca 2+ concentration, … In this study, we aimed to utilize virtual human atrial models …
reticulum Ca 2+ concentration, … In this study, we aimed to utilize virtual human atrial models …
[HTML][HTML] Atrial fibrillation risk loci interact to modulate Ca2+-dependent atrial rhythm homeostasis
B Laforest, W Dai, L Tyan, S Lazarevic… - The Journal of …, 2019 - Am Soc Clin Investig
… atrial arrhythmia susceptibility, prolonged action potential … SR Ca 2+ uptake and SERCA
activity in a mouse model of AF … and SR Ca 2+ uptake, restoring sinus rhythm. SERCA2 and …
activity in a mouse model of AF … and SR Ca 2+ uptake, restoring sinus rhythm. SERCA2 and …