… used agent for maintaining sinus rhythm in patients with AF, … increases the calcium
concentration ([Ca 2+ ] i ) and activates … cardiac midmyocardial action potential duration model as …

… between variation in human atrial ultrastructure and myocyte … -pool model of the human atrial
myocyte action potential (AP) (… rate-dependence in normal sinus rhythm (sr) in experimental …

… tients with atrial fibrillation (AF) compared with normal sinus rhythm (… action potential and
Ca2+ phenotypes. We discovered that a substantial AF-related increase of the background Ca2…

… advanced by work conducted in animal models [33, 34]. … downregulation of inward L-type Ca
2+ current (I CaL ) [39,40,41]… As expected, normal goats in sinus rhythm exhibited atrial APD …

… action potentials and reduced L-type Ca 2+ current contribute to a substantial reduction of
intracellular [Na + ]. These features of Ca 2… altered Ca 2+ signalling in various models of atrial …

… In sinus rhythm (Ctl) the selective M 1 -receptor antagonists … through shortening of the atrial
action potential duration (APD) … We employed computational modeling to analyze the effects …

… to induce action potential firing, reduced low firing action potential … in human tissue over
animal models, is critical for our understanding of neural control of heart function and its potential …

… the primary action potential as a result of spontaneous Ca 2+ … models and patients support
a potential role of SR Ca 2+ … to patients in sinus rhythm. Moreover, contraction of multicellular …

… Asterisk indicates sinus rhythm pacing site, approximately at the … model variants display
distinct action potential and Ca2+ … b), reflecting the atrial heterogeneity observed in cellular …

… assess the model performances, AP features (action po… intracellular Ca2+ transient features
(minimum and maximum Ca2… of abnormal heart rhythms associated with chronic myocardial …