CHDH, a key mitochondrial enzyme, plays a diagnostic role in metabolic disorders diseases and tumor progression

Y Li, X Shen, X Yang, F Lian, Y Li, J Li, Y Huang… - Frontiers in …, 2023 - frontiersin.org
… In recent years, the role of CHDH in medicine has … the difficulties in purifying CHDH,
biochemists lost interest in the enzyme and little is known about the biochemical properties of human

Choline oxidases

G Gadda - The Enzymes, 2020 - Elsevier
… The enzyme is important both for medical and … is an obligatory and thermodynamically
challenging step in the reaction of … A biochemical characterization of a choline oxidase from a …

[HTML][HTML] Choline metabolism and its implications in cancer

N Yao, W Li, G Xu, N Duan, G Yu, J Qu - Frontiers in Oncology, 2023 - ncbi.nlm.nih.gov
… cell metabolites, but human imaging challenges need to be … In conclusion, choline-based
metabolic imaging holds promise … different fields, including biochemistry, molecular biology, …

Understanding choline bioavailability and utilization: first step toward personalizing choline nutrition

YQ Goh, G Cheam, Y Wang - Journal of Agricultural and Food …, 2021 - ACS Publications
… for many age-related health problems, there is a pressing need to … via mitochondrial enzyme
choline dehydrogenase, (60) and … , citicoline is a medicine containing CDP-choline that was …

Common genetic variants alter metabolism and influence dietary choline requirements

AB Ganz, KC Klatt, MA Caudill - Nutrients, 2017 - mdpi.com
… dietary choline (put forth by the National Academies of Medicinepromise of incorporating
common genetic variants into … remains limited and substantial challenges remain for the field. …

Choline kinase: An underappreciated rheumatoid arthritis therapeutic target

AM Jose, M Rasool - Life Sciences, 2022 - Elsevier
… on the metabolomics of a biological system lays forward a … the altered choline metabolism
promises a new dimension in … T cell activation becomes challenging. More recently MRS/…

Osmotic Contribution of Synthesized Betaine by Choline Dehydrogenase Using In Vivo and In Vitro Models of Post-traumatic Syringomyelia

DD Pukale, D Lazarenko, SR Aryal, F Khabaz… - Cellular and Molecular …, 2023 - Springer
… and its synthesis enzyme choline dehydrogenase (CHDH) … known osmoprotectant role
in biological systems, along with … options to overcome challenges associated with clinical …

Applications of deep eutectic solvents in biotechnology and bioengineering—Promises and challenges

YP Mbous, M Hayyan, A Hayyan, WF Wong… - Biotechnology …, 2017 - Elsevier
biological sectors. To date, the applications of DESs have shown great promise, especially
in the medical … is available about ILs, the toxicity of choline-based mixtures hardly could be …

The glycine betaine role in neurodegenerative, cardiovascular, hepatic, and renal diseases: Insights into disease and dysfunction networks

JA Rosas-Rodríguez, EM Valenzuela-Soto - Life sciences, 2021 - Elsevier
… , agriculture, and clinical medical studies due to its chemical and … synthesis: the choline
dehydrogenase and betaine aldehyde … with the progression of health problems, most of the GB …

Understanding and Preventing Disease-Associated Anaerobic Choline Metabolism by the Human Gut Microbiota

S Bodea - 2016 - dash.harvard.edu
… for me, and despite all the challenges, I will forever cherish all … -gut microbe interactions
holds the promise of revealing new … have been set by the Institute of Medicine at 425 mg/day for …