… These 3D cultures could be a useful model for developmental neurotoxicity testing. … 3D
human neural tissues, using neural progenitor cells derived from human embryonic stem cells. …

… The neurotoxicity of cadmium has been extensively … development and has also been
detected in milk during lactation (Korpela et al., 1986). Therefore, the developmental neurotoxicity (…

… For the UKK2 test system, the cells were cultured and maintained in StemMACS iPS-Brew
XF medium (Miltenyi Biotec, Germany) on plates coated with Matrigel (Corning GmbH, …

… transcriptome changes associated with cytotoxic drug concentrations, we challenged the
UKN1 test system … The acute neurotoxic exposure conditions used in the present study showed …

… ) Report on integrated testing strategies for the identi cation and evaluation … developmental
neurotoxicity (DNT). In Report of the OECD/EFSA workshop on developmental neurotoxicity (…

… for assessment of developmental neurotoxicity along with a … Four test systems based on
H9 stem cells and transcriptomic … tionality of human embryonic stem cell-derived hepatocyte- …

… We summarize the main cellular characteristics underlying neurotoxicity, present an …
developmental neurotoxicology, and highlight especially the use of stem cell-based test systems to …

… human (h)ESC testing systems, trying to elucidate their potential for developmental toxicity
testing. It … Another approach is the assessment of suitable transcriptomic and metabolomic …

… test systems for identifying teratogenic effects of drug candidates based on human embryonic
stem cells (hESCs) and human … as a model for developmental neurotoxicity (for review see […

… A human stem cell-derived test system for agents modifying … -based test systems differed
strongly in their transcriptome re… on altered transcriptome patterns in developmental toxicity …