Human leukocyte antigen (HLA) peptides derived from tumor antigens induced by inhibition of DNA methylation for development of drug-facilitated immunotherapy
B Shraibman, DM Kadosh, E Barnea… - Molecular & Cellular …, 2016 - ASBMB
Treatment of cancer cells with anticancer drugs often fails to achieve complete remission.
Yet, such drug treatments may induce alteration in the tumor's gene expression patterns,
including those of Cancer/Testis Antigens (CTA). The degradation products of such antigens
can be presented as HLA peptides on the surface of the tumor cells and be developed into
anticancer immunotherapeutics. For example, the DNA methyl transferase inhibitor, 5-aza-
2′-deoxycytidine (Decitabine) has limited antitumor efficacy, yet it induces the expression …
Yet, such drug treatments may induce alteration in the tumor's gene expression patterns,
including those of Cancer/Testis Antigens (CTA). The degradation products of such antigens
can be presented as HLA peptides on the surface of the tumor cells and be developed into
anticancer immunotherapeutics. For example, the DNA methyl transferase inhibitor, 5-aza-
2′-deoxycytidine (Decitabine) has limited antitumor efficacy, yet it induces the expression …
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