Hypericum perforatum in the treatment of psychiatric and neurodegenerative disorders: Current evidence and potential mechanisms of action
Journal of cellular physiology, 2019•Wiley Online Library
Background Psychiatric disorders are substantially associated with reduced quality of life
and increased mortality. Depression and anxiety are two of the most common psychiatric
disorders that often co‐occur with each other as well as with other mental health conditions.
Because of the limitations of currently available antidepressant therapies, there is a need for
agents with improved efficacy and less adverse effects. Hypericum perforatum, widely
known as St. John's wort, is a perennial herbaceous plant most well known for its …
and increased mortality. Depression and anxiety are two of the most common psychiatric
disorders that often co‐occur with each other as well as with other mental health conditions.
Because of the limitations of currently available antidepressant therapies, there is a need for
agents with improved efficacy and less adverse effects. Hypericum perforatum, widely
known as St. John's wort, is a perennial herbaceous plant most well known for its …
Background
Psychiatric disorders are substantially associated with reduced quality of life and increased mortality. Depression and anxiety are two of the most common psychiatric disorders that often co‐occur with each other as well as with other mental health conditions. Because of the limitations of currently available antidepressant therapies, there is a need for agents with improved efficacy and less adverse effects. Hypericum perforatum, widely known as St. John's wort, is a perennial herbaceous plant most well known for its antidepressant properties.
Methods
We reviewed the available in vitro, in vivo, and clinical evidence on the efficacy, safety, and mechanisms of action of St. John's wort and its active constituents in the treatment of psychiatric and neurodegenerative disorders.
Results
Several interesting data have been reported about the antidepressant properties of H. perforatum in clinical trials with different designs. In particular, a number of antidepressant‐controlled trials demonstrated that H. perforatum and its active ingredients, hypericin and hyperforin, possess antidepressant properties similar to those of tricyclic antidepressants and selective serotonin reuptake inhibitors but with fewer and milder side effects.
Conclusion
St. John's wort may exert potent antidepressant effects and represents an efficacious and safe treatment. However, the current clinical evidence regarding the efficacy of H. perforatum in other psychiatric and neurodegenerative disorders is not sufficient to draw a robust conclusion.
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