Kinins and their B1 and B2 receptors as potential therapeutic targets for pain relief
I Brusco, MFP Fialho, G Becker, ES Brum, A Favarin… - Life Sciences, 2023 - Elsevier
… ), or be evoked by sensory stimuli (hyperalgesia and allodynia). Neuropathic pain is usually
a … mediating physiological actions of kinins in nociception and inflammatory response. It has …
a … mediating physiological actions of kinins in nociception and inflammatory response. It has …
[HTML][HTML] Kinins and their B1 and B2 receptors are involved in fibromyalgia-like pain symptoms in mice
I Brusco, AB Justino, CR Silva, S Fischer… - Biochemical …, 2019 - Elsevier
… In this study reserpine caused behavioural and biochemical alterations related to
fibromyalgia, as previously reported in human and experimental animals [10], [11]. Moreover, …
fibromyalgia, as previously reported in human and experimental animals [10], [11]. Moreover, …
[HTML][HTML] Tibial post fracture pain is reduced in kinin receptors deficient mice and blunted by kinin receptor antagonists
V Minville, L Mouledous, A Jaafar, R Couture… - Journal of Translational …, 2019 - Springer
… knockout mice showed hypoalgesia against inflammatory … control mice, ie WT, B2KO and
B1KO mice without fracture … likely by blunting the inflammatory response of infiltrating cells. The …
B1KO mice without fracture … likely by blunting the inflammatory response of infiltrating cells. The …
Kinin B1 receptors as a therapeutic target for inflammation
F Qadri, M Bader - Expert opinion on therapeutic targets, 2018 - Taylor & Francis
… The first BKB1R antagonists were peptides with a slightly changed … However, a mouse lacking
both kinin receptors although … a marked reduction of inflammatory responses induced in a …
both kinin receptors although … a marked reduction of inflammatory responses induced in a …
[HTML][HTML] Kinin B2 and B1 Receptors Activation Sensitize the TRPA1 Channel Contributing to Anastrozole-Induced Pain Symptoms
MFP Fialho, ES Brum, G Becker, I Brusco, SM Oliveira - Pharmaceutics, 2023 - mdpi.com
… them the altered function of ion channels in sensory neurons, such as Transient Potential …
for 15 days induced pain behavior in mice without causing desensitization, similar to other AIs (…
for 15 days induced pain behavior in mice without causing desensitization, similar to other AIs (…
Kinin B1 receptor promotes neurogenic hypertension through activation of centrally mediated mechanisms
S Sriramula, E Lazartigues - Hypertension, 2017 - Am Heart Assoc
… To dismiss potential developmental alterations in knockout mice… mice (Figure S8). We also
observed that similar to our B1RKO mice, R715 treatment reduced the inflammatory response …
observed that similar to our B1RKO mice, R715 treatment reduced the inflammatory response …
Kinin receptors: Key regulators of autoimmunity
RC Dutra - Autoimmunity reviews, 2017 - Elsevier
… -antigens, the subsequent altered response of the innate and … use of B1 knockout mice
greatly prevented the hyperalgesia (… role in potentiating inflammatory responses within the joint …
greatly prevented the hyperalgesia (… role in potentiating inflammatory responses within the joint …
[HTML][HTML] Kinins' Contribution to Postoperative Pain in an Experimental Animal Model and Its Implications
… (pain in response to normally non-painful stimuli), hyperalgesia (… or surgical procedure in
mice without treatment. For this, … for an exaggerated postoperative inflammatory response and …
mice without treatment. For this, … for an exaggerated postoperative inflammatory response and …
Blockade of the kinin B1 receptor counteracts the depressive-like behaviour and mechanical allodynia in ovariectomised mice
I de Souza Maciel, VM Azevedo, P Oliboni… - Behavioural Brain …, 2021 - Elsevier
… A range of these alterations can accompany women for the … hyperalgesia, which are
associated with the production of the … -induced colitis in mice lacking kinin B(1) receptors through …
associated with the production of the … -induced colitis in mice lacking kinin B(1) receptors through …
[HTML][HTML] The transient receptor potential ankyrin-1 mediates mechanical hyperalgesia induced by the activation of B1 receptor in mice
FC Meotti, CP Figueiredo, M Manjavachi… - Biochemical …, 2017 - Elsevier
… The kinin receptor B 1 and the transient receptor potential … gatekeepers of nociception and
inflammation. This study reports … -inflammatory response triggered by B 1 receptor activation. …
inflammation. This study reports … -inflammatory response triggered by B 1 receptor activation. …