Kinins and their B1 and B2 receptors as potential therapeutic targets for pain relief

I Brusco, MFP Fialho, G Becker, ES Brum, A Favarin… - Life Sciences, 2023 - Elsevier
… ), or be evoked by sensory stimuli (hyperalgesia and allodynia). Neuropathic pain is usually
a … mediating physiological actions of kinins in nociception and inflammatory response. It has …

[HTML][HTML] Kinins and their B1 and B2 receptors are involved in fibromyalgia-like pain symptoms in mice

I Brusco, AB Justino, CR Silva, S Fischer… - Biochemical …, 2019 - Elsevier
… In this study reserpine caused behavioural and biochemical alterations related to
fibromyalgia, as previously reported in human and experimental animals [10], [11]. Moreover, …

[HTML][HTML] Tibial post fracture pain is reduced in kinin receptors deficient mice and blunted by kinin receptor antagonists

V Minville, L Mouledous, A Jaafar, R Couture… - Journal of Translational …, 2019 - Springer
… knockout mice showed hypoalgesia against inflammatory … control mice, ie WT, B2KO and
B1KO mice without fracture … likely by blunting the inflammatory response of infiltrating cells. The …

Kinin B1 receptors as a therapeutic target for inflammation

F Qadri, M Bader - Expert opinion on therapeutic targets, 2018 - Taylor & Francis
… The first BKB1R antagonists were peptides with a slightly changed … However, a mouse lacking
both kinin receptors although … a marked reduction of inflammatory responses induced in a …

[HTML][HTML] Kinin B2 and B1 Receptors Activation Sensitize the TRPA1 Channel Contributing to Anastrozole-Induced Pain Symptoms

MFP Fialho, ES Brum, G Becker, I Brusco, SM Oliveira - Pharmaceutics, 2023 - mdpi.com
… them the altered function of ion channels in sensory neurons, such as Transient Potential …
for 15 days induced pain behavior in mice without causing desensitization, similar to other AIs (…

Kinin B1 receptor promotes neurogenic hypertension through activation of centrally mediated mechanisms

S Sriramula, E Lazartigues - Hypertension, 2017 - Am Heart Assoc
… To dismiss potential developmental alterations in knockout micemice (Figure S8). We also
observed that similar to our B1RKO mice, R715 treatment reduced the inflammatory response

Kinin receptors: Key regulators of autoimmunity

RC Dutra - Autoimmunity reviews, 2017 - Elsevier
… -antigens, the subsequent altered response of the innate and … use of B1 knockout mice
greatly prevented the hyperalgesia (… role in potentiating inflammatory responses within the joint …

[HTML][HTML] Kinins' Contribution to Postoperative Pain in an Experimental Animal Model and Its Implications

I Brusco, CR Silva, J Ferreira, SM Oliveira - Brain Sciences, 2023 - mdpi.com
… (pain in response to normally non-painful stimuli), hyperalgesia (… or surgical procedure in
mice without treatment. For this, … for an exaggerated postoperative inflammatory response and …

Blockade of the kinin B1 receptor counteracts the depressive-like behaviour and mechanical allodynia in ovariectomised mice

I de Souza Maciel, VM Azevedo, P Oliboni… - Behavioural Brain …, 2021 - Elsevier
… A range of these alterations can accompany women for the … hyperalgesia, which are
associated with the production of the … -induced colitis in mice lacking kinin B(1) receptors through …

[HTML][HTML] The transient receptor potential ankyrin-1 mediates mechanical hyperalgesia induced by the activation of B1 receptor in mice

FC Meotti, CP Figueiredo, M Manjavachi… - Biochemical …, 2017 - Elsevier
… The kinin receptor B 1 and the transient receptor potential … gatekeepers of nociception and
inflammation. This study reports … -inflammatory response triggered by B 1 receptor activation. …