Hypothalamic-pituitary-adrenal (HPA) axis activity and anxiety-like behavior during aging: A test of the glucocorticoid cascade hypothesis in amyloidogenic APPswe …
BN Harris, BR Roberts, GM DiMarco… - General and …, 2023 - Elsevier
Alzheimer's disease (AD) is a progressive, dementing, whole-body disorder that presents
with decline in cognitive, behavioral, and emotional functions, as well as endocrine
dysregulation. The etiology of AD is not fully understood but stress-and anxiety-related
hormones may play a role in its development and trajectory. The glucocorticoid cascade
hypothesis posits that levels of glucocorticoids increase with age, leading to dysregulated
negative feedback, further elevated glucocorticoids, and resulting neuropathology. We …
with decline in cognitive, behavioral, and emotional functions, as well as endocrine
dysregulation. The etiology of AD is not fully understood but stress-and anxiety-related
hormones may play a role in its development and trajectory. The glucocorticoid cascade
hypothesis posits that levels of glucocorticoids increase with age, leading to dysregulated
negative feedback, further elevated glucocorticoids, and resulting neuropathology. We …
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