The role of hypoxia in pancreatic cancer: a potential therapeutic target?

M Erkan, M Kurtoglu, J Kleeff - Expert review of gastroenterology & …, 2016 - Taylor & Francis
… correlation between HIF-1 expression and pancreatic cancer aggressiveness, which in fact
… in the mechanism of hypoxia-induced invasiveness of pancreatic cancer cells. These include …

Hypoxia-induced oxidative stress promotes MUC4 degradation via autophagy to enhance pancreatic cancer cells survival

S Joshi, S Kumar, MP Ponnusamy, SK Batra - Oncogene, 2016 - nature.com
… MUC4 expression in PC, and also provided evidence for a novel regulatory mechanism, which
leads to MUC4 degradation due to hypoxia-induced … in PC survival, aggressiveness, drug …

Resveratrol ameliorates the malignant progression of pancreatic cancer by inhibiting hypoxia-induced pancreatic stellate cell activation

Y Xiao, T Qin, L Sun, W Qian, J Li, W Duan… - Cell …, 2020 - journals.sagepub.com
aggressiveness in pancreatic cancer and … hypoxia-induced PSC activation, pancreatic
cancer cell invasion, and apoptosis by inhibiting hypoxia-inducible factor 1α (HIF-1α) expression. …

RER1 enhances carcinogenesis and stemness of pancreatic cancer under hypoxic environment

S Chen, J Zhang, J Chen, Y Wang, S Zhou… - … & Clinical Cancer …, 2019 - Springer
… repressed PC cell proliferation, migration, aggressiveness and tumor formation. It … expression
of HIF-1α increased RER1 expression, demonstrating that the hypoxia-induced PC cell

[HTML][HTML] Modulation of cell physiology under hypoxia in pancreatic cancer

M Estaras, A Gonzalez - World Journal of Gastroenterology, 2021 - ncbi.nlm.nih.gov
lead to significant tissue hypoxia and the aggressiveness, … cell proliferation and in an
increase of chemosensitivity[77]. Overexpression of HIF evoked the expression of hypoxia-induced

Curcumin inhibits hypoxia-induced epithelial‑mesenchymal transition in pancreatic cancer cells via suppression of the hedgehog signaling pathway

L Cao, X Xiao, J Lei, W Duan, Q Ma… - Oncology …, 2016 - spandidos-publications.com
… membranes and enhanced cell invasive ability that facilitate tumor cell invasion into …
hypoxia-induced EMT, we determined the expression levels of EMT-related genes after the cells

Hypoxia: a barricade to conquer the pancreatic cancer

Z Tan, J Xu, B Zhang, S Shi, X Yu, C Liang - Cellular and Molecular Life …, 2020 - Springer
… In addition, hypoxia-induced expression of vascular endothelial growth factor (VEGF) …
MiRNA research offers molecular insight into tumor aggression and carcinogenesis. The mature …

CD133 modulate HIF-1α expression under hypoxia in EMT phenotype pancreatic cancer stem-like cells

K Maeda, Q Ding, M Yoshimitsu, T Kuwahata… - International Journal of …, 2016 - mdpi.com
… ) plays a major role in cancer cell survival and aggressiveness in hypoxia [10]. … pancreatic
cancer cells with CSC characteristics acquired high migratory potential with hypoxia induced

Hypoxia-inducible factor-2α promotes tumor progression and has crosstalk with Wnt/β-catenin signaling in pancreatic cancer

Q Zhang, Y Lou, J Zhang, Q Fu, T Wei, X Sun, Q Chen… - Molecular cancer, 2017 - Springer
… Therefore, pancreatic cancer is assumed to survive in long-term hypoxic conditions via …
hypoxia-induced EMT in four pancreatic cancer cell lines [19]. As expected, hypoxia induced

Enhanced glutaminolysis drives hypoxia-induced chemoresistance in pancreatic cancer

SJ Park, HC Yoo, E Ahn, E Luo, Y Kim, Y Sung, YC Yu… - Cancer Research, 2023 - AACR
… For 3D printing, patient-derived PDAC cells and pancreatic cancer cell lines were
collected by … Pancreatic cancer cells stably expressing a hypoxia response element (HRE)–dependent …