… , mutations frequently affect direct and indirect epigenetic regulators … Yet, molecular details
of how IDH1 mutations alter … , combinatorial mouse models carrying specific Idh1-R132H and …

… examine the transcriptomic changes driven by mutant IDH1/2 … examined epigenetic alterations
in Idh1/2 and Tet2 mutated cells… (51) and HPC-7 mouse progenitors (66, 67) indicated that …

… In this study, using our mouse model and primary patient-… that IDH1 R132H induces
radioresistance in vivo by altering … Our results indicating that IDH1 R132H decreases …

… R140Q in primary murine bone marrow cells … hematopoietic system. However, the range
of 5mC, 5hmC and histone methylation changes detected upon IDHm expression in cells raises …

… In addition, IDH1/2 mutations in vivo contribute to the development of gliomas, leukemias,
cholangiocarcinomas, and sarcomas by increasing the number of stem cells and impairing …

… Development of new mouse models for individual epigenetic … highly orchestrated manner
without altering the primary DNA … , the clonal hematopoiesis is associated with increases in the …

… R172K cooperate to alter normal hematopoiesis, we crossed … hematopoietic progenitors
via epigenetic modifications [31,32… impairment of DNA repair pathways in our mouse model. …

… 1 (IDH1) mutant pHSCs, we show epigenetic, transcriptional, … of the metabolic changes
observed in IDH1 R132H pHSCs, we … knowledge is derived from mouse models with limited study …

… the epigenetic machinery of hematopoietic progenitors; this … CFU ability in mouse model
with the IDH1-R132H mutation; … progenitors and alters epigenetics.” Nature 488 (2012): 656-9…

… Epigenetic changes, including abnormal histone and DNA methylation, have been implicated
in the pathogenic build-up of hematopoietic progenitors… increased immature progenitors …