… : a member of the IκB family of NF-κB inhibitor proteins and the IκB kinase (IKK) complex. …
kinase catalytic activity and instead serves an essential accessory role in activation of NF-κB …

… These kinases are considered master regulators of … described to activate canonical and
noncanonical NF-κB, IKKα … B kinase; IL-1β, interleukin 1β; NEMO, NF-κB essential modulator; …

… hub for NF-κB activation pathways … NF-κB signalling has been the druggable IKKβ kinase
due to foundational mouse studies that indicated IKKβ and NEMO are essential for activation of …

… kinase known to regulate the noncanonical pathway (NF-κB p50/p52), regulates the activation
of the canonical pathway via IκB kinase … an important new pathway activation of NF-κB p50…

… of Thr 172 in its activation loop by the kinase LKB1, CAMKK2, or TAK1. TAK1-… important
target of TAK1 is IκB kinase (IKK), which controls the activation of the transcription factor NF-κB…

… Because IKK and IKK related kinases play a crucial role in the NF-κB activation pathway, …
against these kinases for cancer therapy. Since IKKβ is the primary regulator of NF-κB, most …

… In the non-canonical signaling, an NF-κB-inducing kinase (NIK) activates IKKα, which then
… Thus, NF-κB is important for breast tumor development through RANKL/RANK/IKKα to the …

… NF-κB family, along with its inhibitors (IκB family) and activators (IκB kinase complex), work
together to exert important … Therefore, the capabilities of EcIKKα-1 and -2 to activate NF-κB …

… Here, we identify that NF-κB activation is suppressed by an F-box protein, S-phase kinase
… The degradation of IκB-α is an important landmark of NF-κB activation. We found that SKP2 …

… necessary player in immunity, but contributes primarily through an alternative pathway. After
IκBα proteolysis, the NF-κB … into hydrogen bonding distance to IKK’2 N-terminal αC residues, …