… Further studies are needed to verify whether these factors … our data suggested that NF-κB
plays an essential role in EGF … the major kinase responsible for phosphorylation of all the IκB …

… Receptor-interacting protein 1 kinase is crucial for TNF-induced NF-κB activation,25 and
RIP-deficient cells are susceptible to apoptosis after TNF-α stimulation.Interestingly, RIP works …

… to the activation of two IκB kinases (IKK), IKK-1 and IKK-2, which then phosphorylate IκB at
two N-… Moreover, celastrol inhibits the activation of NF-κB by targeting IκB kinase, which is not …

… as a specific regulator of NF-κB, we needed to rule out its … of SNW1 reduced NF-κB activation
from all stimuli ( Fig. 4C ). … is composed of cyclin-dependent kinase 9 (CDK9) and cyclin T1 (…

… These results suggest the crucial role of the TNF-α-LPA-LPA … as TNF-α, IκB is phosphorylated
by IκB kinases at its specific … allowing NF-κB to undergo nuclear translocation and activate …

… (RPE), although important in the pathogenesis of these … kapa-B kinase subunit beta (IKKβ)
that selectively targets NF-κB … via the orchestrated modulation of IKK-2/IκBα/NF-κB [26]. …

… , the IκB kinase (IKK) complex phosphorylates IκB, which leads … NF-κB-mediated signaling
events in HSC quiescence through a gain-of-function approach. Our data indicate that NF-κB …

… NF-κB and the proteins that regulate NF-κB activation are crucial for B and T cell tolerance
… By contrast, IL-1 receptor ligation activates NF-κB via IRAK (IL-1 receptor-associated kinase…

… Therefore, the inhibition of the bone-resorbing activity of osteoclasts is a crucial target of drugs
… promotes the activation of the IκB kinase complex (IKK), the phosphatidylinositol 3-kinase (…

… selectively in oligodendrocytes and demonstrated that NF-κB activation prevented … that
NF-κB activation contributed to the protective effects of pancreatic ER kinase (PERK) activation on …