TNFα and IL-17 alkalinize airway surface liquid through CFTR and pendrin
T Rehman, IM Thornell, AA Pezzulo… - … of Physiology-Cell …, 2020 - journals.physiology.org
… cultures of differentiated human airway epithelia grown at the air… IL-17 might induce pendrin
expression in a specific cell type. … An airway epithelial IL-17A response signature identifies a …
expression in a specific cell type. … An airway epithelial IL-17A response signature identifies a …
Interleukin-mediated pendrin transcriptional regulation in airway and esophageal epithelia
… from STAT6 but related rather to IL-17A [93]. This was also in … with IL-13 to induce pendrin
expression in HNE cells [92]. … neutrophilic infiltration in human airway epithelial cells may …
expression in HNE cells [92]. … neutrophilic infiltration in human airway epithelial cells may …
Pendrin mediates bicarbonate secretion and enhances cystic fibrosis transmembrane conductance regulator function in airway surface epithelia
… Well-differentiated primary human bronchial epithelial (pHBE… effect of pendrin on CFTR
activity without cytokine induction of … IL-17A (21). We observed apical colocalization of CFTR and …
activity without cytokine induction of … IL-17A (21). We observed apical colocalization of CFTR and …
Pendrin mediates bicarbonate secretion and enhances CFTR function in airway surface epithelia
… of pendrin on CFTR activity without cytokine induction of … IL17A (21). We observed apical
co-localization of CFTR and … -4-stimulated human bronchial epithelial cells: Role of pendrin and …
co-localization of CFTR and … -4-stimulated human bronchial epithelial cells: Role of pendrin and …
The role of pendrin in the airways: links with asthma and COPD
K Izuhara, S Suzuki, C Nofziger, M Ogawa… - … Anion Exchanger, 2017 - Springer
… gene was induced by IL-13 in human airway epithelial cells … pendrin expression was
up-regulated in bronchial epithelial … by Bordetella pertussis is not STAT6-dependent, but IL-17A–…
up-regulated in bronchial epithelial … by Bordetella pertussis is not STAT6-dependent, but IL-17A–…
[HTML][HTML] Airway surface hyperviscosity and defective mucociliary transport by IL-17/TNF-α are corrected by β-adrenergic stimulus
D Guidone, M Buccirossi, P Scudieri, M Genovese… - JCI insight, 2022 - ncbi.nlm.nih.gov
… chloride channel function causes airway surface dehydration… that the treatment of bronchial
epithelia in vitro with IL-17A (IL-17) and … Human bronchial epithelial cells from CF patients (…
epithelia in vitro with IL-17A (IL-17) and … Human bronchial epithelial cells from CF patients (…
Function-specific IL-17A and dexamethasone interactions in primary human airway epithelial cells
SF Rahmawati, R Vos, IST Bos, HAM Kerstjens… - Scientific Reports, 2022 - nature.com
… We further analysed the IL-17A differentially expressed … We demonstrate that IL-17A-induced
inflammation and mucus … , an anion exchange protein which is known to induce goblet …
inflammation and mucus … , an anion exchange protein which is known to induce goblet …
[HTML][HTML] Pendrin, an anion exchanger on lung epithelial cells, could be a novel target for lipopolysaccharide-induced acute lung injury mice
CE Jia, D Jiang, H Dai, F Xiao… - American Journal of …, 2016 - ncbi.nlm.nih.gov
… expression of pendrin on airway epithelium. (B) The administration of LPS could … IL-17A
was also found to induce bicarbonate secretion (a pendrin activity) in human bronchial epithelial …
was also found to induce bicarbonate secretion (a pendrin activity) in human bronchial epithelial …
[HTML][HTML] Pendrin stimulates a chloride absorption pathway to increase CFTR‐mediated chloride secretion from Cystic Fibrosis airway epithelia
J Bajko, M Duguid, S Altmann, GD Hurlbut… - FASEB …, 2020 - ncbi.nlm.nih.gov
… in human bronchial epithelial cell (HBEC) derived epithelia … , and IL‐17a all increased
pendrin protein expression, IL‐17a … Such a large IL‐4 induced, CFTR‐dependent current in the …
pendrin protein expression, IL‐17a … Such a large IL‐4 induced, CFTR‐dependent current in the …
[HTML][HTML] Inhibitors of pendrin anion exchange identified in a small molecule screen increase airway surface liquid volume in cystic fibrosis
PM Haggie, PW Phuan, JA Tan, L Zlock… - The FASEB …, 2016 - ncbi.nlm.nih.gov
… human airway epithelial cells from non-CF and CF subjects, treatment with IL-13, which causes
inflammation with strong pendrin … -13, and IL-17A; 2) rodent models of inflammatory lung …
inflammation with strong pendrin … -13, and IL-17A; 2) rodent models of inflammatory lung …