… inflammation of the adipose tissue, and eventually systemically, is a major driver of obesity-…
The late response of VAT Tregs to an HFD: PPARγ downregulation and up-regulation of pro-…

… and lipolytic genes, while adoptive transfer of Treg cells or … acts as a negative regulator of
Treg cells in hyperinsulinemic … IL-21 is overexpressed in obese adipose tissue and reduces …

… stimulates glucose and fatty acid oxidation and lipolysis [70]. … that IL-21 exerts negative
regulation on Treg activity, favoring … and in Treg/Th17 imbalance influencing metabolic responses…

… expression of IL-21 and IL-10. Interleukin 21 negatively regulates regulatory T-cells in GWAT
… Investigating the role of IL-21 in modulating regulatory T-cells or other immune cell subsets …

… IL-25 increases lipolysis and free fatty acids through adipose … IL-21 expression in T-cells is
modulated by IL-21 in autocrine … repress differentiation of inducible Tregs as demonstrated in …

… the regulation of adipose tissue inflammation, suggesting that … Some other factors such as
leptin, IL-21, and autophagy-… to the pool and function of adipose Treg cells and maintain the …

… In this work we have unveiled IL-21 as a critical negative regulator of Treg cells in the context
… To determine whether IL-21 affected FoxP3 expression also in stable natural Treg cells, we …

… the different aspects of the regulation of homeostasis of … with fatty acids and/or products
derived from adipocyte cell … necrosis factor, Treg regulatory T cell, WAT white adipose tissue …

… Another study showed that high levels of IFN-I induced apoptosis of regulatory T cells (Tregs…
IL-21 has been reported to be a negative regulator of IRF4, and IL-21-deficient mice …

… /6 mice None Expression MHC II in adipocyte was increased in obesity, which … IL-21-null
mice, showed reduced AT inflammation and improved IR due to increased infiltration of Tregs …