Novel desferrioxamine derivatives synthesized using the secondary metabolism-specific nitrous acid biosynthetic pathway in Streptomyces davawensis

R Hagihara, Y Katsuyama, Y Sugai, H Onaka… - The Journal of …, 2018 - nature.com
… A putative desferrioxamine biosynthetic gene cluster was … in the genome of Streptomyces
davawensis JCM 4913 as a … , we identified three novel desferrioxamine derivatives having …

Prediction of gene cluster function based on transcriptional regulatory networks uncovers a novel locus required for desferrioxamine B biosynthesis

HE Augustijn, ZL Reitz, L Zhang, JA Boot, SS Elsayed… - bioRxiv, 2024 - biorxiv.org
… genome analysis identified the novel desJGH gene cluster. … the putative direct regulon of
DmdR1 from 25 to 155 58 genes, … is showcased in our study of Streptomyces coelicolor M145, a …

Iron-meditated fungal starvation by lupine rhizosphere-associated and extremotolerant Streptomyces sp. S29 desferrioxamine production

SA Jarmusch, D Lagos-Susaeta, E Diab, O Salazar… - Molecular omics, 2021 - pubs.rsc.org
… additional previously described were identified, clearly showing a … (III) is toxic and has no
direct role in metabolism and seems to be … S29 des gene cluster is ongoing to link the chemical …

Actinobacteria phylogenomics, selective isolation from an iron oligotrophic environment and siderophore functional characterization, unveil new desferrioxamine traits

P Cruz-Morales, HE Ramos-Aboites… - FEMS Microbiology …, 2017 - academic.oup.com
… data, to direct the future ecological and functional analysis of … of arylated DFOs in Micrococcus
and Streptomyces; as well as a … We then identified and retrieved the des genes found to be …

Biosynthesis of novel desferrioxamine derivatives requires unprecedented crosstalk between separate NRPS-independent siderophore pathways

L Su, Y Souaibou, L Hôtel, C Paris… - Applied and …, 2024 - Am Soc Microbiol
identified DFO-B and -E, produced by both Streptomyces ambofaciens and mutants obtained
by genetic engineering of the stambomycin gene cluster … to obtain more direct evidence for …

Characterization of a broadly specific cadaverine N-hydroxylase involved in desferrioxamine B biosynthesis in Streptomyces sviceus

LA Giddings, GT Lountos, KW Kim, M Brockley… - Plos one, 2021 - journals.plos.org
biosynthetic gene cluster in S. sviceus and proposed enzymatic steps involved in the synthesis
of desferrioxamine … a higher sequence identity to DesB in the industrial desferrioxamine B-…

Production and Potential Genetic Pathways of Three Different Siderophore Types in Streptomyces tricolor Strain HM10

M Rehan, H Barakat, IS Almami, KA Qureshi… - Fermentation, 2022 - mdpi.com
… rings (ie, desferrioxamine B/E from Streptomyces griseus and/or S. … to obtain direct comparisons
among treatments’ means. … identified hydroximate desferrioxamine B/E siderophore from …

The secreted metabolome of Streptomyces chartreusis and implications for bacterial chemistry

CHR Senges, A Al-Dilaimi… - Proceedings of the …, 2018 - National Acad Sciences
desferrioxamine synthesis gene cluster was detected in the genome, yet different sets of
desferrioxamines … above the detection limit, the production of all desferrioxamines parallels the …

Complete genome sequencing and antibiotics biosynthesis pathways analysis of Streptomyces lydicus 103

N Jia, MZ Ding, H Luo, F Gao, YJ Yuan - Scientific reports, 2017 - nature.com
… has unambiguously identified desferrioxamine E as the major desferrioxamine siderophore
… has identified a cluster of four genes (desA-D) that directs desferrioxamine biosynthesis in …

Indentification of a gene cluster involved in desferrioxamine biosynthesis in Gordonia rubripertincta and Pimelobacter simplex

M Mehnert, T Heine, P Sobrado… - … : Recent Advances in …, 2018 - books.google.com
… desABCD was identified in the genome of Streptomyces coelicolor … In this study, we identified
the biosynthetic gene cluster for siderophore … Identification of a cluster of genes that directs