The heavy chain 4F2hc modulates the substrate affinity and specificity of the light chains LAT1 and LAT2
S Kantipudi, JM Jeckelmann, Z Ucurum… - International journal of …, 2020 - mdpi.com
… The human L-type amino acid transporters LAT1 and LAT2 … for the overexpression of
eukaryotic membrane proteins [30,31… identified as a promising candidate for milligram protein …
eukaryotic membrane proteins [30,31… identified as a promising candidate for milligram protein …
Structure/function relationships of the human heterodimeric amino acids transporter 4F2hc/LAT1
… bilayer in which many membrane proteins are included, … ) was identified as the light subunit
that co-expresses with rBAT. This … the other human heavy chain rBAT. 4F2hc gene codified a …
that co-expresses with rBAT. This … the other human heavy chain rBAT. 4F2hc gene codified a …
Contribution of the L-Type amino acid transporter family in the diagnosis and treatment of prostate cancer
X Zhao, S Sakamoto, J Wei, S Pae, S Saito… - International Journal of …, 2023 - mdpi.com
… The first two proteins belong to the solute vector family 7 (… 2.6 million new cases of PCa were
identified each year, with an … ) heavy chain protein to form a transmembrane complex to play …
identified each year, with an … ) heavy chain protein to form a transmembrane complex to play …
Yeast Cell-Based Transport Assay for the Functional Characterization of Human 4F2hc-LAT1 and‐LAT2, and LAT1 and LAT2 Substrates and Inhibitors
S Kantipudi, D Fotiadis - Frontiers in Molecular Biosciences, 2021 - frontiersin.org
… In mammalian cells, the L-type amino acid transporters (LATs… acid transporters requiring the
heavy chain 4F2 (4F2hc) for … towards identification of possible effects of the ancillary protein …
heavy chain 4F2 (4F2hc) for … towards identification of possible effects of the ancillary protein …
Molecular mechanisms of thyroid hormone transport by l-type amino acid transporter
G Krause, KM Hinz - Experimental and Clinical Endocrinology …, 2020 - thieme-connect.com
… Thyroid hormone transporters that have been identified until now belong to two different …
The latter consist of a light chain (e. g. LAT2) and an escort protein as heavy chain (4F2hc), …
The latter consist of a light chain (e. g. LAT2) and an escort protein as heavy chain (4F2hc), …
[HTML][HTML] Novel therapeutic approaches targeting L-type amino acid transporters for cancer treatment
K Hayashi, N Anzai - World journal of gastrointestinal oncology, 2017 - ncbi.nlm.nih.gov
… identified by searching for sequence homology to LAT3[20]. LAT4 is expressed in the basolateral
membrane of … and LAT2, LAT3 as well as LAT4 functions independently of heavy chain. …
membrane of … and LAT2, LAT3 as well as LAT4 functions independently of heavy chain. …
[HTML][HTML] Targeting L-type amino acid transporter 1 in urological malignancy: current status and future perspective
S Pae, S Sakamoto, X Zhao, S Saito, T Tamura… - Journal of …, 2022 - Elsevier
… 12-transmembrane heterodimeric amino acid transporter. LAT1 is disulfide-linked to the SLC3
family members 4F2hc (4F2 heavy chain: … -binding protein-5 (IGFBP-5) was identified as a …
family members 4F2hc (4F2 heavy chain: … -binding protein-5 (IGFBP-5) was identified as a …
Volta phase plate cryo-EM structure of the human heterodimeric amino acid transporter 4F2hc-LAT2
JM Jeckelmann, D Fotiadis - International journal of molecular sciences, 2019 - mdpi.com
… It is associated with the heavy chain subunit 4F2hc (CD98), which is a type II membrane N-…
use of different purification detergents for structure determination resulting in differently sized …
use of different purification detergents for structure determination resulting in differently sized …
Structure of the human heterodimeric transporter 4F2hc-LAT2 in complex with Anticalin, an alternative binding protein for applications in single-particle cryo-EM
JM Jeckelmann, T Lemmin, M Schlapschy, A Skerra… - Scientific reports, 2022 - nature.com
… -associated L-type amino acid … heavy chain 4F2hc shares structural similarities to bacterial
glucosidases but is enzymatically inactive 7,8 . Light chains are polytopic membrane proteins …
glucosidases but is enzymatically inactive 7,8 . Light chains are polytopic membrane proteins …
Sub-nanometer cryo-EM density map of the human heterodimeric amino acid transporter 4F2hc-LAT2
JM Jeckelmann, D Fotiadis - International journal of molecular sciences, 2020 - mdpi.com
… II membrane N-glycoprotein 4F2hc (SCL3A2) and the L-type amino … are referred as the heavy
chains. The two components of … the expression of membrane proteins for structural studies […
chains. The two components of … the expression of membrane proteins for structural studies […