… the discovery of PICK1 small molecule inhibitors using a … in hippocampal neurons cultured
from wild-type and PICK1 … with the PICK1 PDZ domain by crystal structure determination of …

… = 1 μM) (Madsen et al, 2005), we sought to identify the … down PICK1 expression (without
replacement) in the hippocampal … it administration (20 μM) of the small‐molecule PICK1 inhibitor …

… compared to the availability of small molecule databases. … study to identify the best hits
against the PICK1 PDZ domain. … domain that inhibits hippocampal LTP and LTD. Proceedings …

… on hippocampal interneurons through its PDZ coupling with … nAChR binding to the PICK1
PDZ domain by carrying out NMR… To identify residues of α7 nAChR involved in binding PICK1, …

… low sequence identity, making each PDZ domain unique. … -GluR2 interactions abolishes
cerebellar and hippocampal … , successfully developing a PICK1 small-molecule inhibitor with the …

… of the small molecule PICK1 inhibitor FSC231 directly into the … Our findings support the
hypothesis that inhibition of PICK1 … Moreover, we identified systemic doses of the PICK1 inhibitor …

… of small molecule inhibitors to modulate PDZ domains. … used to discover potent small molecule
PICK1-PDZ inhibitors. This … the detection of weakly binding inhibitors for the PDZ domain …

… of small-molecule and peptide modulators of PDZ domains. … The first small-molecule inhibitor
of the PDZ domain in PICK1… long-term potentiation in hippocampal cornu ammonis 1 (CA1) …

… was the first-identified small-molecule inhibitor of PICK1 [44]. … long-term potentiation in
hippocampal cornu ammonis 1 (CA1) … , here we will focus on the small-molecule inhibitor BIO124 (…

… Effective small molecule inhibitors that target unique PDZ domains might be useful for the …
recognized by PDZ domains. For instance, mGluR7 interacts with the PICK-1 PDZ domain to …