Commensal orthologs of the human autoantigen Ro60 as triggers of autoimmunity in lupus
TM Greiling, C Dehner, X Chen, K Hughes… - Science Translational …, 2018 - science.org
… Ro60 ortholog–containing commensal bacteria are common in the human skin, oral, and …
Given that we identified commensal bacterial reactivity also with autoreactive human memory T …
Given that we identified commensal bacterial reactivity also with autoreactive human memory T …
A molecular basis of human T cell receptor autoreactivity toward self-phospholipids
A Shahine, I Van Rhijn, TY Cheng, S Iwany… - Science …, 2017 - science.org
… studies have identified a role for CD1b in T cell autoreactivity, … protruding ligand,
forming many contacts that mediate high … binds to most major classes of endogenous self-phospholipids, …
forming many contacts that mediate high … binds to most major classes of endogenous self-phospholipids, …
Human autoreactive T cells recognize CD1b and phospholipids
I Van Rhijn, T Van Berlo, T Hilmenyuk… - Proceedings of the …, 2016 - National Acad Sciences
… scan through the major classes of phospholipids, we identified … broadly in human T-cell
responses to other types of bacteria is … ligands on the surface, rather than the failure to recognize …
responses to other types of bacteria is … ligands on the surface, rather than the failure to recognize …
Apoptosis in response to microbial infection induces autoreactive TH17 cells
… MHC class II molecules present self antigens and non-self … deliver TLR ligands along with
cellular and microbial antigens … Thus, our study has identified a mechanism by which infection …
cellular and microbial antigens … Thus, our study has identified a mechanism by which infection …
Expression of the DNA-binding factor TOX promotes the encephalitogenic potential of microbe-induced autoreactive CD8+ T cells
… Our results identify TOX as a transcriptional regulator of … a high potential to generate
long-lived memory T cells with self-… Neither OT-1 expansion nor the disease course was altered …
long-lived memory T cells with self-… Neither OT-1 expansion nor the disease course was altered …
Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity
… discrimination by a human, preproinsulin reactive, MHC class-I… ligands have been identified
and characterized for a human … ligand to break self-tolerance and prime self-reactive T cells. …
and characterized for a human … ligand to break self-tolerance and prime self-reactive T cells. …
Cross-reactivity with self-antigen tunes the functional potential of naive B cells specific for foreign antigens
HR Steach, BL DeBuysscher, A Schwartz… - The Journal of …, 2020 - journals.aai.org
… To prevent Ab-mediated autoimmunity, self-reactive B cells are … Studies of individual Ab
lineages have identified isolated … with self-peptide bound to MHC class I was associated with …
lineages have identified isolated … with self-peptide bound to MHC class I was associated with …
MR1, an immunological periscope of cellular metabolism
A Chancellor, A Vacchini… - International …, 2022 - academic.oup.com
… identified so far do not respond to the same microbial antigens as MAIT cells, are self-reactive …
the plasma membrane and present self-antigens or microbial ligands acquired in the ER …
the plasma membrane and present self-antigens or microbial ligands acquired in the ER …
[HTML][HTML] γδ T cell responses: How many ligands will it take till we know?
D Vermijlen, D Gatti, A Kouzeli, T Rus… - Seminars in cell & …, 2018 - Elsevier
… the identification and validation of putative γδ T cell ligands … -natal microbial exposure [33],
therefore arguing against ligand-… T cells whilst preventing autoreactivity toward metabolically …
therefore arguing against ligand-… T cells whilst preventing autoreactivity toward metabolically …
Age‐associated B cells: key mediators of both protective and autoreactive humoral responses
… has recently been identified in both mice and humans. These … both autoantigens and certain
classes of pathogens provide … ABCs with responses to self ligands bearing similar properties…
classes of pathogens provide … ABCs with responses to self ligands bearing similar properties…