[HTML][HTML] Identifying proteomic risk factors for overall, aggressive and early onset prostate cancer using Mendelian randomization and tumor spatial transcriptomics
TA Desai, ÅK Hedman, M Dimitriou, M Koprulu, S Figiel… - medRxiv, 2023 - ncbi.nlm.nih.gov
Background Understanding the role of circulating proteins in prostate cancer risk can reveal
key biological pathways and identify novel targets for cancer prevention. Methods We
investigated the association of 2,002 genetically predicted circulating protein levels with risk
of prostate cancer overall, and of aggressive and early onset disease, using cis-pQTL
Mendelian randomization (MR) and colocalization. Findings for proteins with support from
both MR, after correction for multiple-testing, and colocalization were replicated using two …
key biological pathways and identify novel targets for cancer prevention. Methods We
investigated the association of 2,002 genetically predicted circulating protein levels with risk
of prostate cancer overall, and of aggressive and early onset disease, using cis-pQTL
Mendelian randomization (MR) and colocalization. Findings for proteins with support from
both MR, after correction for multiple-testing, and colocalization were replicated using two …
[HTML][HTML] Identifying proteomic risk factors for overall, aggressive, and early onset prostate cancer using Mendelian Randomisation and tumour spatial transcriptomics
TA Desai, ÅK Hedman, M Dimitriou, M Koprulu… - …, 2024 - thelancet.com
Background Understanding the role of circulating proteins in prostate cancer risk can reveal
key biological pathways and identify novel targets for cancer prevention. Methods We
investigated the association of 2002 genetically predicted circulating protein levels with risk
of prostate cancer overall, and of aggressive and early onset disease, using cis-pQTL
Mendelian randomisation (MR) and colocalisation. Findings for proteins with support from
both MR, after correction for multiple-testing, and colocalisation were replicated using two …
key biological pathways and identify novel targets for cancer prevention. Methods We
investigated the association of 2002 genetically predicted circulating protein levels with risk
of prostate cancer overall, and of aggressive and early onset disease, using cis-pQTL
Mendelian randomisation (MR) and colocalisation. Findings for proteins with support from
both MR, after correction for multiple-testing, and colocalisation were replicated using two …
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