… Additional sources include xanthine oxidase and … free radical NO⁎ (nitric oxide) as an
important vasorelaxant factor … vary according to the underlying pathophysiological process. While …

… compromised function of the nitric oxide synthase (NOS) system … The underlying
pathophysiological mechanisms are … This enzyme is a variant of xanthine oxidoreductase (XOR) …

… , and its activities underlie cardiovascular diseases like … This relationship can be due to the
signaling pathways of NO and PGs, … of nitric-oxide synthase-I (NOS-I)-dependent nitric oxide …

… in vivo and in vitro, and explored the underlying mechanisms. Yeast extract-induced
hyperuricemia animal model as well as hypoxanthine and xanthine oxidase (XOD) co-induced high …

… is upregulated and inhibits xanthine oxidoreductase, leading to … /NO signaling could be one
of the underlying mechanisms … due to the critical balance between NO and peroxynitrite (one …

… the nitric oxide (NO) formation by NO synthase and increase its potential to uncouple and
produce . These conditions reduce XOR affinity for xanthine … The underlying mechanism is …

… mainly produced from NADPH oxidase, xanthine oxidase, … of ET and trigger the downstream
signaling pathways to cause … The primary mechanism underlying NO bioavailability decline …

… seems to be a major underlying mechanism for hyperuricemia-induced … The xanthine
oxidoreductase (XOR) is the key and rate-… cell homeostasis via two main signaling pathways: (1) …

… Endothelial nitric oxide synthase … Generally, these latter mechanisms underlie some of the
contrasting and … are more promiscuous and affect multiple signaling pathways [135]. Similarly, …

… phosphate oxidase (NADPH oxidase) and xanthine oxidase … in L-arginine availability
for nitric oxide synthase (NOS) and … as an important mechanism underlying decreased NO …