… immunotherapy is based upon the principle that adaptations in immune surveillance and
the tumor … mutated DNA of altered proteins which are antigenic, and which serve as tumoral …

… will summarize immune alterations in HNSCC and the rationale behind immunotherapy
strategies … are more likely to develop head and neck cancer and prognosis is relatively poor [8]. …

… These data suggest that HNSCC tumors are prime candidates for trials of anti-KIR … confirmed
that copy number alteration in tumors was inversely correlated with immune cell infiltration (…

… alterations in the epidermal growth factor receptor (EGFR) or anaplastic lymphoma kinase
(ALK) genes were randomized to receive either pembrolizumab … are not optimal candidates for …

… immunotherapy has the potential to enhance clinical outcomes by increasing anti-tumor
immune responses in the presence of abundant tumor-… of histologic changes is understood. …

… toward stimulating immunity in cancer. This article reviews the immunotherapies currently in
… enhance response rates and integrate immunotherapy into the definitive-treatment setting. …

… and future prospects of immunotherapeutic strategies for overcoming immune escape of …
, key genetic or epigenetic changes that favour tumour immune escape, and the strategies that …

… to the seven steps of Cancer-Immunity Cycle as proposed by … such as HPV, genetic alterations,
neoantigens and smoking … and neck tumours making the former better candidates for IO. …

… Currently, the majority of head and neck cancers present with … perceived by host immune
system as the “altered self” and … , HNSCCs represent good candidates for immunotherapy, …

… tumor immune environment and response to immunotherapy … bring transformative changes
to immune-priming strategies. … full spectrum of key genetic alterations. New murine HNSCC …