Immunity to fungi in the lung

LJ Heung, DL Wiesner, K Wang, A Rivera… - Seminars in immunology, 2023 - Elsevier
… antifungal immunity. We emphasize the role of different anatomic sites and cellular crosstalk
in maintaining sterilizing anti-fungal immunity in the lung and in the pathogenesis of fungus-…

Pathogenic fungal infection in the lung

Z Li, G Lu, G Meng - Frontiers in immunology, 2019 - frontiersin.org
… and chemokines, which are predominant regulators in the infectious microenvironment,
mediating the cellular and molecular immune responses against a fungal infection in the lung. …

Innate and adaptive immune responses to fungi in the airway

KR Bartemes, H Kita - Journal of Allergy and Clinical Immunology, 2018 - Elsevier
… hosts fungi can colonize and infect the lungs and other organs, causing increases in
morbidity and mortality. Alternatively, fungi and their products can cause exaggerated immune

[HTML][HTML] Immunity against fungi

MS Lionakis, ID Iliev, TM Hohl - JCI insight, 2017 - ncbi.nlm.nih.gov
… For example, humans inhale infectious conidia or desiccated fungal cells of all genera listed
under lungs and respiratory tree. For other sites, such as the liver, spleen, and blood stream…

Lung epithelial cells coordinate innate lymphocytes and immunity against pulmonary fungal infection

N Hernández-Santos, DL Wiesner, JS Fites… - Cell host & …, 2018 - cell.com
… ” immune cells, particularly in the context of fungal infection. … for immunity against the
pulmonary fungal pathogen Blastomyces dermatitidis. LECs orchestrate innate antifungal immunity

[HTML][HTML] T cell immunity to commensal fungi

A Scheffold, P Bacher… - Current opinion in …, 2020 - Elsevier
… cells can also contribute to immune pathology in distant organs such as the lung via cross-…
Fungi interact with the immune system via molecular patterns triggering innate immune

Immunity to fungi in the lung.

D Wiesner, K Wang, A Rivera, T Hohl, L Heung - 2023 - escholarship.org
… antifungal immunity. We emphasize the role of different anatomic sites and cellular crosstalk
in maintaining sterilizing anti-fungal immunity in the lung and in the pathogenesis of fungus

Sterilizing immunity in the lung relies on targeting fungal apoptosis-like programmed cell death

N Shlezinger, H Irmer, S Dhingra, SR Beattie… - Science, 2017 - science.org
immune surveillance remains unclear. By monitoring fungal physiology in vivo, we demonstrate
that lung … An antiapoptotic protein, AfBIR1, opposes this process by inhibiting fungal

Anti-fungal T cell responses in the lung and modulation by the gut-lung axis

A Scheffold, P Bacher - Current Opinion in Microbiology, 2020 - Elsevier
… Further the microbiota, influence anti-fungal immunity in the lung via non-specific (innate)
and antigen-specific modulation, including cross-reactivity to related and unrelated antigens. …

Human airway epithelium responses to invasive fungal infections: A critical partner in innate immunity

AJ Crossen, RA Ward, JL Reedy, MV Surve, BS Klein… - Journal of Fungi, 2022 - mdpi.com
… components of the immune system are critical for the swift clearance of fungal pathogens.
Still… by lung epithelium, immune cells are vital to the containment and clearance of fungi. Upon …