… A very recent study has shown that HLA hyperexpression is strongly correlated with STAT1
expression in beta cell-containing islets from type 1 diabetes patients [1]. STAT2 was not …

… and natural killer cells [71]; and 3) Th1 multiactivity induced by IFNα therapy enhances the
… response to β cells and accelerates the destruction of β cells, leading to type 1 diabetes [72]. …

… as both positive and negative modulators of type 1 diabetes disease risk dependent on sex.
… of autoimmune diabetes (type 1 diabetes [T1D]) has been studied for more than 30 years (1). …

… Immunoreactive alpha-interferon in insulin-secreting beta … Islet βcell endoplasmic
reticulum stress precedes the onset of type 1 diabetes in the nonobese diabetic mouse model. …

… Pancreas samples from type 1 diabetes patients with residual … Organ donors with Diabetes
(nPOD), Diabetes Virus Detection study (… of beta cells in their own demise in type 1 diabetes. …

… Our study identifies increased responsiveness to IFN-1 as a … diabetes and human established
type 1 diabetes. A stimulated IFN-1 gene signature may be a potential biomarker for type 1 …

… allele for type 1 diabetes in ARGI induces an hyperactivation of type I IFN response in β cells,
… The immunoreactive bands were detected using a Bio-Rad Molecular Imager ChemiDoc …

… T cells in T1D patients (8). This line of evidence certainly points to β cell defects contributing
to diabetes pathogenesis; however, this study does not address what might cause β cells to …

… In conclusion, we could consider that the major vulnerability in type 1 diabetes is the β cell
itself, as the target organ that becomes damaged, and requires protection. CD8 + cytotoxic T …

… loss of pancreatic β cells, and damage to β cells because of … in the number of insulin-secreting
granules in β cells, loss of … in organ tropism and induces α-interferon production. The E …