… dimerization, resulting in deficient IRF3 transcriptional activity and impaired IFN response of
… was shown to impair trafficking on TLR1 to the cell surface, and monocytes homozygous for …

… the signaling pathway, activating expression of type I IFNs, is induced [73, 74]. AP3-deficient
mice have defective … LPS-tolerized human monocytes and THP1 cells showed impaired Lyn …

… Monocytes are precursors of macrophages and key players … , colonic macrophages from
mice with defective IL-10R signaling or … These results suggested that the impaired recognition of …

… cell types, including monocytes, macrophages, neutrophils, and … , is diminished in
C5aR2-deficient macrophages. This finding … also in macrophages, which are thereby impaired for …

… In contrast, Ang-II treated TLR4 deficient mice showed increased catalase activity compared
… and improved immune function 42 . In the present study, our results showing impaired ATP …

… To examine the human relevance of this finding, human monocyte derived macrophages
(… no impairment in the phagocytosis of E. coli, but double heterozygotes were defective in …

… , resulting in impairment of both diastolic and systolic functions, … that the cardiac function
in TLR4-deficient mice was not … Activated TLR4 in monocytes plays an important role in the …

… Our data do not support the hypothesis of globally impaired immune responses in moderate
preterm and term CB monocytes, but rather match the clinical observation that this patient …

… from pathogens or damaged host cells. As a result, the outcome of TLR signaling is
agonist- … Besides dendritic cells, monocytes and macrophages (which also have antigen-presenting …

… ; released and/expressed by damaged/killed host cells). Upon recognition of MAMPs and
DAMPs, TLRs activate downstream signaling pathways releasing several pro-inflammatory …