Therapeutic angiogenesis using autologous adipose-derived regenerative cells in patients with critical limb ischaemia in Japan: a clinical pilot study

T Katagiri, K Kondo, R Shibata, R Hayashida… - Scientific Reports, 2020 - nature.com
… ADRC implantation for therapeutic angiogenesis in patients … progenitor cells show an
increase after ADRC implantation, … angiogenic and cytoprotective effects of ADRC implantation. …

[HTML][HTML] Treatment with adipose-derived regenerative cells enhances ischemia-induced angiogenesis via exosomal microRNA delivery in mice

T Kato, K Kato, Y Shimizu, M Takefuji… - Nagoya Journal of …, 2021 - ncbi.nlm.nih.gov
Implantation of ADRCs improves blood perfusion recovery in CLI states of animals and
humans. Currently, the paracrine effect of ADRCs, including secretion of several growth factors, …

[HTML][HTML] Platelet-rich plasma enhances adipose-derived stem cell-mediated angiogenesis in a mouse ischemic hindlimb model

CF Chen, HT Liao - World Journal of Stem Cells, 2018 - ncbi.nlm.nih.gov
… the in vitro angiogenic effect of platelet-rich plasma (PRP) treated adipose-derived stem
cells (ADSCs) … with PRP before cell implantation, which improved the angiogenic potential of …

Therapeutic angiogenesis for patients with no-option critical limb ischemia by adipose-derived regenerative cells: TACT-ADRC multicenter trial

Y Shimizu, K Kondo, R Hayashida, K Sasaki… - Angiogenesis, 2022 - Springer
Implantation of adipose-derived regenerative cells (ADRCs) has an angiogenic potential for
… degrees of ischemia that can often delay wound healing and increase amputation risk [1]. …

Human adipose-derived stem cells enriched with VEGF-modified mRNA promote angiogenesis and long-term graft survival in a fat graft transplantation model

F Yu, N Witman, D Yan, S Zhang, M Zhou… - … cell research & therapy, 2020 - Springer
enhanced the viability of implanted hADSCs leading to better … had significantly lower
ischemia-induced necrosis when … capable of attenuating ischemia-induced fibrosis, apoptosis, …

Wound healing and angiogenesis through combined use of a vascularized tissue flap and adipose-derived stem cells in a rat hindlimb irradiated ischemia model

S Yoshida, H Yoshimoto, A Hirano… - Plastic and reconstructive …, 2016 - journals.lww.com
… The embedded specimens were sectioned (5 μm) along the longitudinal axis of implantation;
… to investigate the difference of enhanced green fluorescent protein–adipose-derived stem …

No influence on tumor growth by intramuscular injection of adipose-derived regenerative cells: safety evaluation of therapeutic angiogenesis with cell therapy

J Suzuki, Y Shimizu, K Tsuzuki, Z Pu… - American Journal …, 2021 - journals.physiology.org
… In conclusion, local implantation of ADRCs promotes angiogenesis in response … Implantation
of adipose-derived regenerative cells (ADRCs) augments ischemia-induced angiogenesis. …

Rationale and Design of Therapeutic Angiogenesis by Cell Transplantation Using Adipose-Derived Regenerative Cells in Patients With Critical Limb Ischemia―TACT …

Y Shimizu, K Kondo, Y Fukumoto, M Takamura… - Circulation …, 2020 - jstage.jst.go.jp
… treatment promotes neovascularization and improves major amputation-free survival rates …
rate in participants with therapeutic angiogenesis following ADRC implantation based on our …

Therapeutic angiogenesis with adipose tissue-derived regenerative cells

T Murohara, K Kondo - Therapeutic Angiogenesis, 2017 - Springer
… properties of adipose-derived regenerative cells (ADRCs) … Implantation of ADRCs augmented
ischemia-induced … control-released bFGF enhanced angiogenesis in a murine ischemic …

[HTML][HTML] Coadministration of adipose-derived stem cells and control-released basic fibroblast growth factor facilitates angiogenesis in a murine ischemic hind limb …

H Horikoshi-Ishihara, M Tobita, S Tajima… - Journal of Vascular …, 2016 - Elsevier
… induces angiogenesis by several-fold in comparison to implantsenhanced the viability
and proliferation of ASCs and reduced their apoptosis, and it also enhanced the angiogenic