Improving adherence to long-term opioid therapy guidelines to reduce opioid misuse in primary care: a cluster-randomized clinical trial

JM Liebschutz, Z Xuan, CW Shanahan… - JAMA internal …, 2017 - jamanetwork.com
Importance Prescription opioid misuse is a national crisis. Few interventions have improved
adherence to opioid-prescribing guidelines. Objective To determine whether a
multicomponent intervention, Transforming Opioid Prescribing in Primary Care (TOPCARE;
http://mytopcare. org/), improves guideline adherence while decreasing opioid misuse risk.
Design, Setting, and Participants Cluster-randomized clinical trial among 53 primary care
clinicians (PCCs) and their 985 patients receiving long-term opioid therapy for pain. The …
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