Untranslated regions of brain-derived neurotrophic factor mRNA control its translatability and subcellular localization

I Lekk, F Cabrera-Cabrera, G Turconi… - Journal of Biological …, 2023 - ASBMB
mRNA is enriched in rat brain synaptoneurosomes, with higher enrichment detected for exon
I–containing transcripts. … UTRs on mRNA translatability in rat primary cortical neurons and …

Fear extinction is regulated by the activity of long noncoding RNAs at the synapse

WS Liau, Q Zhao, A Bademosi, RS Gormal… - Nature …, 2023 - nature.com
… We previously found activity-dependent epigenetic regulation … used markers for the dendritically
localized scaffold protein PSD-… transcripts, with similar numbers of genes and transcripts

[PDF][PDF] The neuronal gene arc encodes a repurposed retrotransposon gag protein that mediates intercellular RNA transfer

ED Pastuzyn, CE Day, RB Kearns, M Kyrke-Smith… - Cell, 2018 - cell.com
… To test whether Arc release in EVs is activity dependent, we … fer Arc mRNA into neurons, we
measured Arc mRNA levels … and high levels of transferred Arc mRNA after 4h of incubation …

A massively parallel reporter assay reveals focused and broadly encoded RNA localization signals in neurons

M Mikl, D Eletto, M Nijim, M Lee, A Lafzi… - Nucleic Acids …, 2022 - academic.oup.com
transporting specific transcripts into dendrites or axons, where they are available for local
(and sometimes activity-dependent… of the entire pool of dendritically localized mRNAs (10,11), …

The m6A epitranscriptome: transcriptome plasticity in brain development and function

I Livneh, S Moshitch-Moshkovitz, N Amariglio… - Nature Reviews …, 2020 - nature.com
… RNA transcripts with information additional to that carried in … activity-dependent chemical
tagging of groups of transcripts … the dendritically localized, highly methylated, synaptic mRNA

Ethanol-induced behavioral sensitization alters the synaptic transcriptome and exon utilization in DBA/2J mice

MA O'Brien, RM Weston, NU Sheth, S Bradley… - Frontiers in …, 2018 - frontiersin.org
mRNA transport has been shown to occur in an activity dependent manner. For instance, …
for enrichment of known dendritically-trafficked and somatically-restricted transcripts using qRT-…

Synaptic paths to neurodegeneration: the emerging role of TDP‐43 and FUS in synaptic functions

SC Ling - Neural Plasticity, 2018 - Wiley Online Library
transporting RNA granules provide a pathway to regulate synaptic strength through localized
translation [19]. In fact, dendritically localized mRNAs … for activity-dependent translation [85]. …

[HTML][HTML] Role of immediate-early genes in synaptic plasticity and neuronal ensembles underlying the memory trace

K Minatohara, M Akiyoshi, H Okuno - Frontiers in molecular …, 2016 - frontiersin.org
… promote Arc mRNA synthesis in the nucleus and transport to … Arc translation from dendritically
localized Arc mRNA, resulting … physiological roles of activity-dependent IEG expression in …

Chronic morphine intoxication reduces binding of HuD to BDNF long 3′-UTR, while morphine withdrawal stimulates BDNF expression in the frontal cortex of male …

D Peregud, L Panchenko… - International Journal of …, 2022 - Taylor & Francis
… BDNF mRNA by calcium signals evoked via depolarization [Citation42]. Activity-dependent
translational … Somatically synthesized BDNF promotes spine formation, whereas dendritically

A cAMP/PKA-dependent synaptically targeted lncRNA mediates structural plasticity in hippocampal neurons by functionally interacting with the Spectrin/Ankyrin …

E Grinman, Y Nakahata, Y Avchalumov, I Espadas… - bioRxiv, 2020 - biorxiv.org
… is globally upregulated and dendritically localized at 30 min and … activity dependent intronic
lncRNA that is expressed and distally transported to synapses independent of its host mRNA