Untranslated regions of brain-derived neurotrophic factor mRNA control its translatability and subcellular localization
I Lekk, F Cabrera-Cabrera, G Turconi… - Journal of Biological …, 2023 - ASBMB
… mRNA is enriched in rat brain synaptoneurosomes, with higher enrichment detected for exon
I–containing transcripts. … UTRs on mRNA translatability in rat primary cortical neurons and …
I–containing transcripts. … UTRs on mRNA translatability in rat primary cortical neurons and …
Fear extinction is regulated by the activity of long noncoding RNAs at the synapse
… We previously found activity-dependent epigenetic regulation … used markers for the dendritically
localized scaffold protein PSD-… transcripts, with similar numbers of genes and transcripts …
localized scaffold protein PSD-… transcripts, with similar numbers of genes and transcripts …
[PDF][PDF] The neuronal gene arc encodes a repurposed retrotransposon gag protein that mediates intercellular RNA transfer
ED Pastuzyn, CE Day, RB Kearns, M Kyrke-Smith… - Cell, 2018 - cell.com
… To test whether Arc release in EVs is activity dependent, we … fer Arc mRNA into neurons, we
measured Arc mRNA levels … and high levels of transferred Arc mRNA after 4h of incubation …
measured Arc mRNA levels … and high levels of transferred Arc mRNA after 4h of incubation …
A massively parallel reporter assay reveals focused and broadly encoded RNA localization signals in neurons
… transporting specific transcripts into dendrites or axons, where they are available for local
(and sometimes activity-dependent… of the entire pool of dendritically localized mRNAs (10,11), …
(and sometimes activity-dependent… of the entire pool of dendritically localized mRNAs (10,11), …
The m6A epitranscriptome: transcriptome plasticity in brain development and function
I Livneh, S Moshitch-Moshkovitz, N Amariglio… - Nature Reviews …, 2020 - nature.com
… RNA transcripts with information additional to that carried in … activity-dependent chemical
tagging of groups of transcripts … the dendritically localized, highly methylated, synaptic mRNA …
tagging of groups of transcripts … the dendritically localized, highly methylated, synaptic mRNA …
Ethanol-induced behavioral sensitization alters the synaptic transcriptome and exon utilization in DBA/2J mice
… mRNA transport has been shown to occur in an activity dependent manner. For instance, …
for enrichment of known dendritically-trafficked and somatically-restricted transcripts using qRT-…
for enrichment of known dendritically-trafficked and somatically-restricted transcripts using qRT-…
Synaptic paths to neurodegeneration: the emerging role of TDP‐43 and FUS in synaptic functions
SC Ling - Neural Plasticity, 2018 - Wiley Online Library
… transporting RNA granules provide a pathway to regulate synaptic strength through localized
translation [19]. In fact, dendritically localized mRNAs … for activity-dependent translation [85]. …
translation [19]. In fact, dendritically localized mRNAs … for activity-dependent translation [85]. …
[HTML][HTML] Role of immediate-early genes in synaptic plasticity and neuronal ensembles underlying the memory trace
K Minatohara, M Akiyoshi, H Okuno - Frontiers in molecular …, 2016 - frontiersin.org
… promote Arc mRNA synthesis in the nucleus and transport to … Arc translation from dendritically
localized Arc mRNA, resulting … physiological roles of activity-dependent IEG expression in …
localized Arc mRNA, resulting … physiological roles of activity-dependent IEG expression in …
Chronic morphine intoxication reduces binding of HuD to BDNF long 3′-UTR, while morphine withdrawal stimulates BDNF expression in the frontal cortex of male …
D Peregud, L Panchenko… - International Journal of …, 2022 - Taylor & Francis
… BDNF mRNA by calcium signals evoked via depolarization [Citation42]. Activity-dependent
translational … Somatically synthesized BDNF promotes spine formation, whereas dendritically …
translational … Somatically synthesized BDNF promotes spine formation, whereas dendritically …
A cAMP/PKA-dependent synaptically targeted lncRNA mediates structural plasticity in hippocampal neurons by functionally interacting with the Spectrin/Ankyrin …
E Grinman, Y Nakahata, Y Avchalumov, I Espadas… - bioRxiv, 2020 - biorxiv.org
… is globally upregulated and dendritically localized at 30 min and … activity dependent intronic
lncRNA that is expressed and distally transported to synapses independent of its host mRNA…
lncRNA that is expressed and distally transported to synapses independent of its host mRNA…