N-Methyl-D-Aspartate (NMDA) receptor modulators: a patent review (2015-present)

H Ahmed, A Haider, SM Ametamey - Expert opinion on therapeutic …, 2020 - Taylor & Francis
… functional and pharmacological facets of NMDA receptors … that subtype-selective NMDA
receptor antagonists show an … the search for new disease areas with potential NMDA receptor …

Implication of Genes for the N-Methyl-d-Aspartate (NMDA) Receptor in Substance Addictions

J Chen, Y Ma, R Fan, Z Yang, MD Li - Molecular neurobiology, 2018 - Springer
addictions, including dependence on nicotine (ND), alcohol (… In addition, by applying the
NMDAR antagonist MK-801, this … in the pharmacologic properties of the NMDA receptor subunits…

Clinical benefits and risks of N-methyl-d-aspartate receptor antagonists to treat severe opioid use disorder: a systematic review

D Fluyau, N Revadigar, CG Pierre - Drug and Alcohol Dependence, 2020 - Elsevier
… Opioids can inhibit or potentiate NMDA receptor-mediated … are NMDAR antagonists in
the market to treat medical and … for the search was: "N-methyl-d-aspartate and/or opioid use

A novel NMDA receptor-based intervention to suppress compulsion-like alcohol drinking

SA Wegner, B Hu, TDO Sergio, D Darevsky… - …, 2019 - Elsevier
… We found that non-canonical N-methyl-d-aspartate receptors (… to pathological drinking,
NMDAR blockers might serve as … pharmacological interventions did not alter regular, alcohol-…

Ultimate translation: developing therapeutics targeting on N-methyl-d-aspartate receptor

GE Tsai - Advances in Pharmacology, 2016 - Elsevier
Searching for a novel mechanism of antidepressants has … of other NMDAR antagonists
suggests that NMDA antagonism per … competitive antagonist would elicit a safer pharmacological

Pharmacology of NMDA (N-Methyl-D-Aspartate) Receptor Antagonists in Alzheimer's Disease

CWP Schmidt - Pharmacological Treatment of Alzheimer's Disease …, 2022 - Springer
… NMDAR antagonistsantagonists were researched to treat neuropathological and
neurodegenerative diseases. However, the only NMDAR-targeted drug with satisfying therapeutic …

NMDA antagonist treatment of depression

NR Williams, AF Schatzberg - Current opinion in neurobiology, 2016 - Elsevier
N-methyl-d-aspartate (NMDA) glutamate receptor antagonist [9… Other NMDA antagonist
drugs efficacy like memantine [63] … electroconvulsive therapy (ECT) in the sense that searching

… of Anticancer Drug Efficacy in Murine Hepatocellular Carcinoma Cells by a Peripherally Acting Competitive N-Methyl-d-aspartate (NMDA) Receptor Antagonist

M Gynther, I Proietti Silvestri, JC Hansen… - Journal of medicinal …, 2017 - ACS Publications
… competitive NMDA receptor antagonist for use as an augmentative drug for the treatment of
… o/w) values of −0.4 to 5.6 (22) for oral bioavailability, we believed that these NMDA receptor …

An update on NMDA antagonists in depression

B Pochwat, G Nowak, B Szewczyk - Expert review of …, 2019 - Taylor & Francis
… Thus, the search for better acting agents is a continuous process. One of the primary targets
… of new antidepressant drugs is the glutamate N-methyl-D-aspartate (NMDA) receptor. …

The recognition and management of protracted alcohol withdrawal may improve and modulate the pharmacological treatment of alcohol use disorder

F Caputo, M Cibin, A Loche… - Journal of …, 2020 - journals.sagepub.com
… (GABA) and N-methyl-d-aspartate (NMDA) systems, naltrexone, … medications in order to
control PAW (NMDA antagonists and GABA agonists) rather than to immediately reduce alcohol