In vitro methods for in vitro-in vivo correlation (IVIVC) for poorly water soluble drugs: lipid based formulation perspective
… effective delivery of poorly water soluble drugs (PWSDs). Using these drug delivery strategies,
… that SDLFs enhance the oral bioavailability of lipophilic and poorly water soluble drugs. …
… that SDLFs enhance the oral bioavailability of lipophilic and poorly water soluble drugs. …
[HTML][HTML] In vitro and in vivo correlation for lipid-based formulations: Current status and future perspectives
… of poorly water-soluble drugs. However, construction of in vitro and in vivo correlations (…
The lipophilic products of the breakdown of dietary fats (fatty acids and monoglycerides), as …
The lipophilic products of the breakdown of dietary fats (fatty acids and monoglycerides), as …
In vitro-in vivo correlation in the effect of cyclodextrin on oral absorption of poorly soluble drugs
R Aihara, R Messerschmid, M Mizoguchi… - International Journal of …, 2021 - Elsevier
… was observed to assess whether diffusion in an unstirred water layer (UWL) or in a lipophilic
… The effects of water-soluble cyclodextrins on the histological integrity of the rat nasal …
… The effects of water-soluble cyclodextrins on the histological integrity of the rat nasal …
In vitro-in vivo correlation using in silico modeling of physiological properties, metabolites, and intestinal metabolism
SM Choi, CY Kang, BJ Lee, JB Park - Current Drug Metabolism, 2017 - ingentaconnect.com
… In the simulation of poorly water-soluble samples, it may … Fenofibrate is a neutral, lipophilic
compound with a very low … and a typical example of a poorly water-soluble drug [10]. Table 2 …
compound with a very low … and a typical example of a poorly water-soluble drug [10]. Table 2 …
Oral delivery of highly lipophilic, poorly water-soluble drugs: self-emulsifying drug delivery systems to improve oral absorption and enable high-dose toxicology …
XQ Chen, T Ziemba, C Huang, M Chang, C Xu… - Journal of …, 2018 - Elsevier
… As demonstrated later in mouse PK studies, the in vitro dispersion test correlates relatively
well with in vivo oral exposure and can be used as the first-tier assay for quick assessment of …
well with in vivo oral exposure and can be used as the first-tier assay for quick assessment of …
In vitro/in vivo correlations: fundamentals, development considerations, and applications
Y Qiu, JZ Duan - Developing Solid Oral Dosage Forms, 2017 - Elsevier
… correlation between the in vitro dissolution and the in vivo absorption for IR dosage forms of
highly water soluble drugs … large bowel due to inadequate lipophilicity or involvement of gut …
highly water soluble drugs … large bowel due to inadequate lipophilicity or involvement of gut …
[HTML][HTML] Liposomes for enhanced bioavailability of water-insoluble drugs: In vivo evidence and recent approaches
MK Lee - Pharmaceutics, 2020 - mdpi.com
… water-soluble drugs, protect the drug from degradation in the … vitro and in vivo correlation
in order to justify the use of an in … Fenofibrate is a lipophilic drug used to treat abnormal lipid …
in order to justify the use of an in … Fenofibrate is a lipophilic drug used to treat abnormal lipid …
In vitro biphasic dissolution tests and their suitability for establishing in vitro-in vivo correlations: A historical review
A Pestieau, B Evrard - European Journal of Pharmaceutical Sciences, 2017 - Elsevier
… vivo drug release and dissolution characteristics of formulations of poorly water-soluble drugs.
… partitions into the organic layer, exploiting the lipophilicity of the compound. In this way, in …
… partitions into the organic layer, exploiting the lipophilicity of the compound. In this way, in …
Toward successful cyclodextrin based solubility-enabling formulations for oral delivery of lipophilic drugs: solubility–permeability trade-off, biorelevant dissolution, and …
N Fine-Shamir, A Beig, M Zur, D Lindley… - Molecular …, 2017 - ACS Publications
The purpose of this work was to investigate key factors dictating the success/failure of
cyclodextrin-based solubility-enabling formulations for oral delivery of low-solubility drugs. We …
cyclodextrin-based solubility-enabling formulations for oral delivery of low-solubility drugs. We …
Evaluating the role of solubility in oral absorption of poorly water‐soluble drugs using physiologically‐based pharmacokinetic modeling
C Fink, D Sun, K Wagner, M Schneider… - Clinical …, 2020 - Wiley Online Library
… II/IV drugs, such as naproxen, phenytoin, and diazepam, have an absolute bioavailability
(F) > 90%.6, 7 Second, although poorly water-soluble, lipophilic … in vitro–in vivo correlation. …
(F) > 90%.6, 7 Second, although poorly water-soluble, lipophilic … in vitro–in vivo correlation. …