… lignans were the four largest classes of derivatives, the majority of which had IC 50 values low
enough to indicate that natural product derivatives … in (−)-cubebin to lactone resulted in the …

… cruzi activity, and two derivatives were able to induce cure in … and harmonized models in
vitro and in vivo, Citation227 … in this review, sesquiterpene lactone class of natural substances …

… to the genus Trypanosoma, Trypanosoma cruzi is the … to select 11 lignans with potential
activity against L. major and 21 … The in vivo intramuscular treatment with the lactone-rich extract …

… The authors describe that this lignan induced alterations on the parasite structure, but did …
A, as well as the conjugated ketone in the lactone ring. Both electrophilic moieties display an …

… the mode of action of these natural compounds, mainly lignans, neo- lignans, and flavonoids
… (Saururaceae) displayed anti-Trypanosoma cruzi activity via alterations in the mitochondrial …

… great diversity of derivatives groups such as … lactone guaianonobilin (83) was isolated from
A. nobilis flowers and exhibited high activity, with IC50 of 10.9 µM against trypomastigotes of T…

… Several secondary metabolites, or their derivatives, have been found to be the answer in the
quest to … A special place among SM is occupied by lignans and neolignans. These phenolic …

… Chagas disease (CD), also known as American trypanosomiasis, is a parasitic infection
caused by the kinetoplastid protozoan Trypanosoma cruzi, which is naturally transmitted by the …

… The extract was also tested for its activity against the parasite Trypanosoma cruzi, which …
showed the presence of four dibenzylbutirolactone lignans and derivatives: savinin, cubebin, 3,4…

… In addition, much attention should be given when comparing the reported antitrypanosomal
activities of some sesquiterpene and lignan lactones to those of the butanolides, due to other …