Inhaled β2 adrenergic agonists and other cAMP-elevating agents: therapeutics for alveolar injury and acute respiratory disease syndrome?
K Sriram, MB Insel, PA Insel - Pharmacological Reviews, 2021 - ASPET
… approved for the treatment of obstructive lung disease via actions mediated by β2 adrenergic
… , in particular LABAs, for the treatment of acute respiratory distress syndrome (ARDS). We …
… , in particular LABAs, for the treatment of acute respiratory distress syndrome (ARDS). We …
Characterization of an in vitro 3D Human Small Airway Epithelia model for the application of integrated strategies in inhaled drug development
I Masotto - 2021 - iris.univr.it
… technology, as well as inhaler device technology, now allow … human alveolar epithelial cells
and pulmonary microvascular … Drugs with high potential to cause severe lung toxicity belong …
and pulmonary microvascular … Drugs with high potential to cause severe lung toxicity belong …
Combination therapy with budesonide and acetylcysteine alleviates LPS-induced acute lung injury via the miR-381/NLRP3 molecular axis
H Yu, M Lv, S Zhang, K Zou, Y Qian, S Lv - PLoS One, 2023 - journals.plos.org
… symptoms such as acute hypoxia, alveolar epithelial and endothelial damage, and neutrophil
… In the present study, we treated lung epithelial cell lines and SD rats with LPS to establish …
… In the present study, we treated lung epithelial cell lines and SD rats with LPS to establish …
The anti-inflammatory effects of long-acting beta-agonists on bronchial epithelium
N Yang - 2020 - open.library.ubc.ca
… staple of Chronic Obstructive Pulmonary Disease (COPD) maintenance treatment frequently
… such as salbutamol, are typically used as rescue medication to combat acute exacerbations […
… such as salbutamol, are typically used as rescue medication to combat acute exacerbations […
Nanomedicines targeting respiratory injuries for pulmonary disease management
… respiratory injuries, acute lung injury, and acute respiratory … the injury of alveolar epithelial
cells and pulmonary capillary … terbutaline and salbutamol effectively improve the pulmonary …
cells and pulmonary capillary … terbutaline and salbutamol effectively improve the pulmonary …
Evaluation of the histopathological effects of salbutamol inhaler treatment in an experimentally induced rat model of pulmonary contusion
BD DEMİREL, T Ayçiçek, S Gün… - Turkish Journal of …, 2018 - journals.tubitak.gov.tr
… In a clinical trial involving acute lung injury, inhaled salbutamol was reported to reduce … that
salbutamol inhaler therapy had a negative effect on the scores of the contralateral lung tissue…
salbutamol inhaler therapy had a negative effect on the scores of the contralateral lung tissue…
Inhalation of ambroxol inhibits cigarette smoke-induced acute lung injury in a mouse model by inhibiting the Erk pathway
L Ge, Y Liu, X Lin, H Shen, Y Jia, X Dong, Y Sun… - International …, 2016 - Elsevier
… Most importantly, the relevance between these events and COPD was established by the
discovery of a significantly elevated Erk-1/2 activity in airway and alveolar epithelial cells of …
discovery of a significantly elevated Erk-1/2 activity in airway and alveolar epithelial cells of …
Epithelial permeability in asthma
PW Dennison - 2017 - eprints.soton.ac.uk
… Existing treatments do not address the epithelial damage directly, … effects on epithelial
healing. Our hypothesis was that modification of the epithelium, in effect boosting its repair using …
healing. Our hypothesis was that modification of the epithelium, in effect boosting its repair using …
Alveolar type 2 progenitor cells for lung injury repair
AM Olajuyin, X Zhang, HL Ji - Cell death discovery, 2019 - nature.com
… Acute lung injury (ALI) and acute respiratory distress … and replacement of injured alveolar
epithelium with fibrotic … ALI treated with inhaled salbutamol displayed no important improvement…
epithelium with fibrotic … ALI treated with inhaled salbutamol displayed no important improvement…
[HTML][HTML] Lipoxin A4 promotes lung epithelial repair whilst inhibiting fibroblast proliferation
S Zheng, VK D'Souza, D Bartis, RCA Dancer… - ERJ Open …, 2016 - Eur Respiratory Soc
… 4 receptor null mouse models of acute lung injury is essential for confirmation of these results.
… . In vivo and in vitro effects of salbutamol on alveolar epithelial repair in acute lung injury. …
… . In vivo and in vitro effects of salbutamol on alveolar epithelial repair in acute lung injury. …