… Dopamine and drug reward A common feature of addictive drugs is their capacity to reinforce
behavior and to act as powerful rewards in their own right. The simple notion that drugs of …

… also have high affinity for the dopamine D 3 receptor (D3R) (8… distinguish between D2R
and D3R occupancy (9). Though … -biased SGA to an ex vivo slice of mouse PFC modulates Ca …

… In humans, in vivo imaging of D2-like receptors with [ 11 C] … with D3R, D3nf decreases the
capacity of D3R to interact with … (ST 198) and less specific (nafadotride) D3R antagonist also …

… , and in vivo … D2-Rs activation, the ability of D 2L -R and individual D 2L -R mutants to inhibit
forskolin-mediated activation of adenylyl cyclase was also measured to assess their capacity …

… supersensitivity in rats and that the dose of haloperidol used achieved more than 80%
dopamine D 2 receptor occupancy in the striatum. Taken together, these findings suggest that …

… had comparable in vitro proclivity for D2 and D3 receptors, yet … Nafadotride and U99194,
two prototypical D3R preferring … Occupancy of brain dopamine D3 receptors and drug craving: …

The dopamine D3 receptor (D3R) plays a prominent role in the modulation of cognition in
healthy individuals, as well as in the pathophysiological mechanism underlying the cognitive …

… Our in vitro results demonstrate that SK609 has very weak affinity for DAT, even at higher
concentrations, suggesting the doses used in vivo in this study are unlikely to produce a DAT-…

… stimulation in subjects with low DA synthesis capacity is not limited … D2-receptors (co-administration
of quinpirole and nafadotride… D2 receptor binding relates to DAergic activity in vivo. A …

… assays, we will test the in vitro activities of insulin, exendin-4, … in vivo electrical activities of
ventral tegmental area dopamine … determine their capacity to induce tritiated dopamine release …