… be effective against Candida strains, including azole-resistant strains, in vitro and in vivo (23…
, the vast majority of reported fluconazole resistance originates from activating mutations in …

… Additionally, the absence of ERG11 gene mutations and … in the development of azole-resistant
C. tropicalis are warranted. … a possibility of treatment failure in vivo in patients having prior …

… glabrata antifungal resistance in vivo, we utilized a mouse … frequency of resistance-conferring
mutations in vivo. … Drug concentrations of mutant selection plates were 16- to 32-fold …

… glabrata strain with a single nucleotide mutation in the chitin … growth under both in vitro
and in vivo iron-limiting conditions. The … Some alterations are exclusively found in azole-resistant …

… fluconazole in vivo, overexpression of Erg11 or a double mutant … more lethal in petite-negative
C. albicans relative to … - (AGY47) by selecting for spontaneous mutants able to grow on …

… glabrata and the derived deletion mutant cell suspensions … The selected concentration was
found to be inhibitory under … In that species, an azole-resistant isolate showed altered sterol …

… In the azole-resistant strain derived from the CBS138 strain, CBS138_Psc, a mutation in the
… GOF mutations, induced by drug exposure, natural selection favours cells harbouring these …

… For the supply of Candida glabrata mutants used in this work, I … efflux pump overexpressed
in azole resistant strains. As far as … In vivo studies of emergent drug resistance mechanisms …

… Species including as Candida albicans, Candida glabrata, Candida dubliniensis and …
selected were those smaller than the control (without inhibitor). The identity of the petite mutants …

… mutation in PDR1 from an azole-resistant clinical isolate that results in the upregulation of all
three ABC transporters that have been shown to influence azole susceptibility in C… selected …