[HTML][HTML] Sensitization of TRPV1 by protein kinase C in rats with mono-iodoacetate-induced joint pain

K Koda, K Hyakkoku, K Ogawa, K Takasu, S Imai… - Osteoarthritis and …, 2016 - Elsevier
… compared with neuropathic pain model at the molecular level. To confirm involvement of
PKCɛ in the development of enhanced TRPV1 function in knee joints of MIA rats, we used PKC …

Differential contributions of peripheral and central mechanisms to pain in a rodent model of osteoarthritis

AR Haywood, GJ Hathway, V Chapman - Scientific reports, 2018 - nature.com
… knee osteoarthritis 34 which supports our data that TRPV1 … MIA for pain but that TRPV1
did not play a role. Our data add … predictive utility of animal models of osteoarthritis. Arthritis …

TRPV1 alleviates osteoarthritis by inhibiting M1 macrophage polarization via Ca2+/CaMKII/Nrf2 signaling pathway

Z Lv, X Xu, Z Sun, YX Yang, H Guo, J Li, K Sun… - Cell death & …, 2021 - nature.com
… In this study, we investigated the role of TRPV1 in … level of Nrf2 after TRPV1 activation.
Western blot analyses showed that the TRPV1 activation by CPS treatment significantly increased

An update on targets for treating osteoarthritis pain: NGF and TRPV1

AM Obeidat, A Donner, RE Miller - Current treatment options in …, 2020 - Springer
… NGF levels are elevated in different disease states, … treatment showed improved pain
and function compared with … pain behaviour in two rat models of osteoarthritis. Annals of the …

Molecular understanding of the activation of CB1 and blockade of TRPV1 receptors: implications for novel treatment strategies in osteoarthritis

J Mlost, M Kostrzewa, N Malek, K Starowicz - International journal of …, 2018 - mdpi.com
… to be effective analgesics in various animal models of chronic pain, … , enhanced cAMP levels
lead to TRPV1 phosphorylation … studies confirmed a functional role of TRPV1 in a lowered …

[HTML][HTML] Attenuation of early phase inflammation by cannabidiol prevents pain and nerve damage in rat osteoarthritis

HT Philpott, M O'Brien, JJ McDougall - Pain, 2017 - journals.lww.com
… A functional ECS has been demonstrated in the joints of animals 36 and humans, 31 which
… are colocalized with pronociceptive transient receptor potential vanilloid-1 (TRPV1) channels …

[HTML][HTML] Comparison of joint degeneration and pain in male and female mice in DMM model of osteoarthritis

HS Hwang, IY Park, JI Hong, JR Kim, HA Kim - Osteoarthritis and cartilage, 2021 - Elsevier
… density per cage may explain the lack of more severe change in males at early stage in our
… whether TRPV1 plays a role in sex difference in pain and analgesia in OA animal model. …

Anti-inflammatory and analgesic effects of TRPV1 polypeptide modulator APHC3 in models of osteo-and rheumatoid arthritis

YA Logashina, YA Palikova, VA Palikov, VA Kazakov… - Marine drugs, 2021 - mdpi.com
osteoarthritis (OA), which causes chronic pain affecting morejoint inflammation also
indicates the important role of TRPV1 … , was elevated by the usage of two rat models of arthritis: …

[HTML][HTML] Role of TrkA signalling and mast cells in the initiation of osteoarthritis pain in the monoiodoacetate model

J Sousa-Valente, L Calvo, V Vacca, R Simeoli… - Osteoarthritis and …, 2018 - Elsevier
… Indeed, extracellular NGF levels are higher in inflamed joints … the spinal cord in the MIA
model 6 , we counted more c-Fos-… mediate the pro-nociceptive effect of NGF in TrkA KI joints in …

[PDF][PDF] The effects of intra-articular resiniferatoxin on monosodium iodoacetate-induced osteoarthritic pain in rats

Y Kim, E Kim, KS Lee, K Lee, SH Park… - The Korean Journal …, 2016 - synapse.koreamed.org
… Regulation of calcitonin gene-related peptide and TRPV1 in a rat model of osteoarthritis
Increased function of pronociceptive TRPV1 at the level of the joint in a rat model of osteoarthritis