The aquaporin-4 water channel as a potential drug target in neurological disorders

AS Verkman, AJ Smith, P Phuan… - Expert opinion on …, 2017 - Taylor & Francis
… was increased in AQP4 null vs. wild-type mice [Citation46], and electrically induced seizures
Mice lacking AQP4 show less brain swelling following water intoxication and ischemic …

Modulation of posttraumatic epileptogenesis in aquaporin4 knockout mice

JI Szu, DD Patel, S Chaturvedi, JW Lovelace… - …, 2020 - Wiley Online Library
channel AQP4. Absence of AQP4 … lead to hippocampal SRSs and mice lacking AQP4
exhibited significantly longer seizure duration compared with WT mice. Future studies utilizing this …

[HTML][HTML] Mechanisms underlying aquaporin-4 subcellular mislocalization in epilepsy

JI Szu, DK Binder - Frontiers in Cellular Neuroscience, 2022 - frontiersin.org
… processes is the astrocyte water channel aquaporin-4 (AQP4). … mice lacking AQP4 exhibited
an increase in electrographic … On the other hand, the prolonged seizure duration may be …

Aquaporin-4 reduces post-traumatic seizure susceptibility by promoting astrocytic glial scar formation in mice

DC Lu, Z Zador, J Yao, F Fazlollahi… - Journal of …, 2021 - liebertpub.com
… The glial water channel, aquaporin-4 (AQP4), was shown to … to seizures is significantly
higher in mice lacking AQP4 in a … this 20-min period, and length of seizures was unrelated to …

Aquaporin-4 dysregulation in a controlled cortical impact injury model of posttraumatic epilepsy

JI Szu, S Chaturvedi, DD Patel, DK Binder - Neuroscience, 2020 - Elsevier
… Two key players are the astrocytic water channel aquaporin-4 (… The mean seizure duration
was analyzed with Kruskal–… was mostly preserved in injured mice without PTE suggesting a …

The role of aquaporin-4 in synaptic plasticity, memory and disease

JA Hubbard, JI Szu, DK Binder - Brain research bulletin, 2018 - Elsevier
… that provide a pathway for water transport (Nagelhus and … Aquaporin-4 (AQP4), a bidirectional
water channel protein, is the … Water regulation is particularly important because increases

Aquaporin-4 inhibition attenuates Pentylenetetrazole-induced behavioral seizures and cognitive impairments in kindled rats

F Rostami, M Janahmadi, N Hosseinmardi - Physiology & Behavior, 2024 - Elsevier
… involved in regulating neural excitability is the astrocytic water channel aquaporin-4 [11,14]. …
clonic seizures in mice lacking AQP4. Moreover, the duration of stimulation-evoked seizures

Aquaporin-4 water channel in the brain and its implication for health and disease

S Mader, L Brimberg - Cells, 2019 - mdpi.com
Aquaporin-4 (AQP4) is a water channel expressed on … Interest in AQP4 has increased since
it was discovered to be the target … AQP4 deficient mice show a more pronounced phenotype …

[HTML][HTML] The role of astrocytic aquaporin-4 in synaptic plasticity and learning and memory

JI Szu, DK Binder - Frontiers in integrative neuroscience, 2016 - frontiersin.org
… as well as an increased electrographic seizure threshold and electrographic seizure duration
after … and behavioral changes in mice lacking this astrocyte water channel is still unknown. …

Regulation of astrocyte glutamate transporter-1 (GLT1) and aquaporin-4 (AQP4) expression in a model of epilepsy

JA Hubbard, JI Szu, JM Yonan, DK Binder - Experimental neurology, 2016 - Elsevier
Aquaporin-4 (AQP4) is the main water channel in the brain and spinal cord and is …
Increased levels were found at 1 day post SE (after a long duration of high intensity seizures) with …