Aquaporin4 knockout mice exhibit increased hypnotic susceptibility to ketamine

Y Lv, W Dai, A Ge, Y Fan, G Hu, Y Zeng - Brain and behavior, 2018 - Wiley Online Library
… Ketamine blocks nicotinic acetylcholine ion channels, increases dopaminergic and … or
down-regulation leads to increased seizure duration associated with aberrant neuronal activity (…

[HTML][HTML] The potential roles of aquaporin 4 in malignant gliomas

YL Lan, X Wang, JC Lou, XC Ma, B Zhang - Oncotarget, 2017 - ncbi.nlm.nih.gov
Aquaporin 4 (AQP4) is the major water channel expressed in the central nervous system …
To date, more than 13 water channel proteins (AQP1-13) have been identified in multiple …

Aquaporins in neurological disorders

L Hirt, M Price, C Benakis… - Clinical and Translational …, 2018 - journals.sagepub.com
Mice lacking AQP4 develop less pronounced cerebral … −/− mice were more vulnerable to
epileptic seizures than WT … transient cerebral ischemia in aquaporin-4 knockout mice. J Cereb …

Chronic inhibition of astrocytic aquaporin-4 induces autistic-like behavior in control rat offspring similar to maternal exposure to valproic acid

S Davoudi, M Rahdar, N Hosseinmardi, G Behzadi… - Physiology & …, 2023 - Elsevier
… In the present study, we demonstrated that the VPA-exposed offspring had increased
hippocampal water content, and a higher proportion of the fluid volume in this region of the brain as …

Aquaporin 4 is involved in chronic pain but not acute pain

G Lu, C Pang, Y Chen, N Wu, J Li - Behavioural brain research, 2020 - Elsevier
Aquaporin 4 (AQP4), the predominant water channel exists … pain, no differences in the
durations of licking the injected … -/- mice were significantly higher than those of AQP4 +/+ mice 5–…

Astrocyte-Selective Volume Increase in Elevated Extracellular Potassium Conditions Is Mediated by the Na+/K+ ATPase and Occurs Independently of Aquaporin 4

E Walch, TR Murphy, N Cuvelier, M Aldoghmi… - ASN …, 2020 - journals.sagepub.com
increases. Astrocyte swelling in ^[K + ] o was not dependent on neuronal firing, aquaporin 4,
the inwardly rectifying potassium channel … during seizure (10.5 mM), to a concentration more

Aquaporin-4 deficiency facilitates fear memory extinction in the hippocampus through excessive activation of extrasynaptic GluN2B-containing NMDA receptors

X Wu, JT Zhang, D Li, J Zhou, J Yang, HL Zheng… - …, 2017 - Elsevier
Aquaporin-4 (AQP-4) is the predominant water channel in the brain and primarily expressed
… The freezing behavior of both WT and KO mice increased remarkably without any significant …

Neuromyelitis optica and the evolving spectrum of autoimmune aquaporin4 channelopathies: a decade later

SJ Pittock, CF Lucchinetti - Annals of the new York Academy of …, 2016 - Wiley Online Library
… antibody that targets the astrocytic water channel aquaporin-4), as the … We suspect that the
duration of follow-up may not be long … Mice lacking AQP4 have better outcomes in models of …

Cortical astrogliosis and increased perivascular aquaporin-4 in idiopathic intracranial hypertension

PK Eide, VA Eidsvaag, EA Nagelhus, HA Hansson - Brain research, 2016 - Elsevier
… As astrocytic aquaporin-4 (AQP4) water channels play key … In D (patient 24 – epilepsy)
higher magnification disclosed … significant positive correlation between duration of disease and …

The role of aquaporin4 and transient receptor potential vaniloid isoform 4 channels in the development of cytotoxic edema and associated extracellular diffusion …

M Chmelova, P Sucha, M Bochin… - European Journal of …, 2019 - Wiley Online Library
… Overall, our results indicate that the AQP4 and TRPV4 channels may play a crucial role in …
and enhanced cell swelling. However, detailed interplay between AQP4 and TRPV4 channels