Aquaporin-4 and GPRC5B: old and new players in controlling brain oedema

EMJ Passchier, S Kerst, E Brouwers, EMC Hamilton… - Brain, 2023 - academic.oup.com
… We identified a novel homozygous variant in AQP4, encoding the water channel aquaporin-4,
in … Defects in ion and water homeostasis are associated with increased risk of epilepsy, 24 …

Functional role of aquaporins in the nervous system under normal and pathological conditions

ME Shchepareva, MN Zakharova - Neurochemical Journal, 2020 - Springer
… of the central nervous system, aquaporin 4 (AQP4) is a target for … AQP4-deficient mice showed
an increased seizure frequency … seizure duration, which points to the connection between …

Water exchange across the blood–brain barrier and epilepsy: Review on pathophysiology and neuroimaging

M Abdennadher, S Jacobellis, L Václavů… - Epilepsia …, 2024 - Wiley Online Library
… This review focuses on abnormal water exchange in epilepsy and describes … Increased
seizure duration and slowed potassium kinetics in mice lacking aquaporin- 4 water channels. Glia…

Aquaporins in nervous system

M Xu, M Xiao, S Li, B Yang - Aquaporins, 2017 - Springer
… is a bidirectional water channel that facilitates water transport … However, deletion of AQP4
in mice does impair extracellular … reduced seizure threshold and increased seizure duration […

Aquaporin-4 expression during toxic and autoimmune demyelination

SO Rohr, T Greiner, S Joost, S Amor, P van der Valk… - Cells, 2020 - mdpi.com
… for IgG autoantibodies against the astrocyte water channel aquaporin-4 (AQP4), called
AQP4-… null mice have normal intracranial pressure and only slightly increased total brain water

A de novo Ser111Thr variant in aquaporin-4 in a patient with intellectual disability, transient signs of brain ischemia, transient cardiac hypertrophy, and progressive …

S Berland, TL Toft-Bertelsen… - Molecular …, 2018 - molecularcasestudies.cshlp.org
Aquaporin-4, encoded by AQP4, is the major water channel in the central nervous system …
increasing tendency to fall that has developed in the last years, he has never had any seizures

The role of aquaporins in spinal cord injury

TA Garcia, CR Jonak, DK Binder - Cells, 2023 - mdpi.com
… The aquaporin-4 (AQP4) water channel is found on plasma … Clearance of seizure-induced
edema may also be AQP4-… AQP4 −/− mice showed significantly decreased stride length in …

Molecular mechanisms of brain water transport

N MacAulay - Nature Reviews Neuroscience, 2021 - nature.com
… To obtain the best experience, we recommend you use a more … the proposed role for the glial
water channels, aquaporins (AQPs)… Aquaporin 4 (AQP4) and the K + -transporting proteins (…

Targeted deletion of Aqp4 promotes the formation of astrocytic gap junctions

S Katoozi, N Skauli, S Rahmani, LMA Camassa… - Brain Structure and …, 2017 - Springer
Aquaporin-4 (AQP4) is the predominant water channel in the … Our findings suggest that AQP4
KO leads to increasedMice lacking both Cx30, and Cx43 in astrocytes (Cx30 −/− Cx43 fl/fl /…

Caveolin-1 regulates perivascular aquaporin-4 expression after cerebral ischemia

I Filchenko, C Blochet, L Buscemi, M Price… - Frontiers in cell and …, 2020 - frontiersin.org
… , neurological deficit, epileptic seizures, body weight loss … a significant increase in the
branch length of astrocytes in the … We show now that mice lacking Cav-1 have significantly less …