[PDF][PDF] Protective Effects of Aquaporin-4 Deficiency on Longer-Term Neurological Outcomes in a Mouse Model of Traumatic Brain Injury

X Liu, Y Xie, X Wan, J Wu, Z Fan, L Yang - 2020 - scholar.archive.org
… that relies on the polarized water channel aquaporin-4 (AQP4) at … cut into sections with a side
length of 4 mm. And isometric … of nerve function leads to convulsions and seizures. Neuroin …

[PDF][PDF] Molecular characterization of a pathogenic Ser111Thr mutation in the astrocytic water channel Aquaporin-4

A Farooq - 2021 - duo.uio.no
Aquaporin-4 (AQP4) is the predominant brain water channel protein. It is mainly localized at
… studies show increased seizure duration in AQP4-null animals, and increased extracellular K…

The role of AQP4 and TRPV4 channels in the ischemic brain edema: focusing on glial cells

D Kročianová - 2019 - dspace.cuni.cz
… a transgenic knockout mouse lacking the mercurial-insensitive water channel aquaporin-4.” …
Increased aquaporin-4 immunoreactivity in rat brain in response to systemic hyponatremia.…

Aquaporin 4 knockout increases complete freund's adjuvant-induced spinal central sensitization

C Wang, Q Wu, Z Wang, L Hu, C Marshall… - Brain Research Bulletin, 2020 - Elsevier
… The water channel protein aquaporin 4 (AQP4), a functional regulator of astrocytes, is … ,
but reduces seizure threshold, and increases seizure duration in epilepsy models (Binder et al., …

[HTML][HTML] Locomotor hyperactivity in the early-stage Alzheimer's disease-like pathology of APP/PS1 mice: associated with impaired polarization of astrocyte aquaporin 4

T Wang, Y Chen, Y Zou, Y Pang, X He, Y Chen… - Aging and …, 2022 - ncbi.nlm.nih.gov
aquaporin 4 (AQP4) and glymphatic transport impairment. Deletion of the AQP4 gene increased
… two open arms (length: 35 cm; width: 5 cm) and two closed arms (length: 35 cm; width: 5 …

The role of aquaporin 4 in brain tumors: implications for pathophysiology, diagnosis and therapy

M Behnam, A Motamedzadeh, M Aalinezhad… - Molecular Biology …, 2022 - Springer
channel that carries a two-way waterIncreased AQP-4 expression level was detected in
glioblastoma membranes in patients with seizures compared with individuals without seizures […

AQP4 Aggravates Cognitive Impairment in Sepsis‐Associated Encephalopathy through Inhibiting Nav1.6‐Mediated Astrocyte Autophagy

DD Zhu, YL Huang, SY Guo, N Li, XW Yang… - Advanced …, 2023 - Wiley Online Library
… astrocyte-inflammation associated with aquaporin-4 (AQP4). … channel having a high expression
level in astrocytes. It is not … In an experimental model of epilepsy, rats show a significant …

Astrogliosis and impaired aquaporin4 and dystrophin systems in idiopathic normal pressure hydrocephalus

PK Eide, HA Hansson - Neuropathology and Applied …, 2018 - Wiley Online Library
… whether expression of the water channel aquaporin-4 (AQP4) … Aquaporin 4 is the dominating
water channel in the brain, … AQP4 deficiency increases the propensity for seizures 33. In …

[HTML][HTML] Orchestrating aquaporin-4 and connexin-43 expression in brain: Differential roles of α1-and β1-syntrophin

SB Rao, N Skauli, N Jovanovic, S Katoozi… - … et Biophysica Acta (BBA …, 2021 - Elsevier
… high density of aquaporin-4 (AQP4) water channels [4] and … Mice lacking Sntb1 did not differ
from WT controls in regard … protein complex including full length Dystrophin (Dmd) and its …

Astrocyte glutamate uptake and water homeostasis are dysregulated in the Hippocampus of multiple sclerosis patients with seizures

AS Lapato, SM Thompson, K Parra… - ASN …, 2020 - journals.sagepub.com
… neuronal excitability, including water channels (AQP4) and … in the present study may
increase seizure susceptibility by … Loss of perivascular aquaporin 4 may underlie deficient water