… The 26S proteasome activity was monitored by a mutant … core proteasomal peptidase activities
were measured by cell … chymotrypsin-like peptidase activity indirectly. It has been shown …

… are recognized by the 26S proteasome for degradation. The … cellular models (Mitra et al.,
2009). Subsequently, it was proposed that diffuse mHtt might inhibit the proteasome indirectly, …

… proteasome activity indirectly and in a HD mouse model was … ATP-competitive inhibitors
face issues with toxicity due to … a number of different HD cellular and animal models 125,126 . …

… system (UPS) are generally inhibited in HD patient’s brain. We previously … that a proteasome
activator (PA), PA28γ enhances proteasome activities and cell survival in in vitro HD model. …

… model to study ubiquitination dynamics and the role of the Ubiquitin Proteasome System (UPS)
in protein misfolding diseases… in MG132 proteasome inhibitor concentration in cell culture…

… 5 inhibitors) stimulate proteasome activities and intracellular … larvae models of tauopathies
and Huntington’s disease … Because PKG may activate proteasomes indirectly in cells by …

… disease (AD), Huntington’s disease (HD), and amyotrophic … in increasing both 20S and 26S
proteasome-mediated proteolysis, … (123) demonstrated that the indirect antioxidant 3H-1,2-…

… neither competitive nor noncompetitive inhibitors of 26S and … The expression of Rpn4 is
regulated by the 26S proteasome … has any physiological relevance in Huntington’s disease, we …

… inhibition of the proteasome, while autophagy activity was not significantly affected. That
suggests that parkin might also modulate the activity of the 26S proteasome in our cell model by …

… of the tagged protein by the 26S proteasome complex. The … diseases such as Alzheimer,
Parkinson and Huntington … as a direct/indirect proteasome inhibitor under our experimental …