In vitro inhibition and reversal of Plasmodium falciparum cytoadherence to endothelium by monoclonal antibodies to ICAM-1 and CD36

KMF Mustaffa, J Storm, M Whittaker, T Szestak… - Malaria journal, 2017 - Springer
… is caused by an interaction between the parasite protein … on pRBC associated with placenta
malaria and subsequent … than the adhesion itself or the induction of cross-reactive immunity …

Adhesion of Plasmodium falciparum infected erythrocytes in ex vivo perfused placental tissue: a novel model of placental malaria

…, A Salanti, M Resende, R Dzikowski, P Damm… - Malaria journal, 2016 - Springer
… model of parasite adhesion in intact placental tissue. … endemic regions develop protective
antibodies during childhood. … of a vaccine to induce antibodies that inhibit the binding of …

Reduced risk of placental parasitemia associated with complement fixation on Plasmodium falciparum by antibodies among pregnant women

DH Opi, MJ Boyle, ARD McLean, L Reiling, JA Chan… - BMC medicine, 2021 - Springer
Parasite accumulation in the placenta is a key feature of MiP following infection with Plasmodium
falciparum [2… the complement fixing activity of antibodies induced by vaccines based on …

Malaria Parasite Plasmodium falciparum Proteins on the Surface of Infected Erythrocytes as Targets for Novel Drug Discovery

AV Oleinikov - Biochemistry (Moscow), 2022 - Springer
antibodies preventing IE cytoadhesion to the placental syncytiotrophoblast in multigravid
women is associated with protection against … PM, and is characterized by induction of adhesion …

Functional antibodies against placental malaria parasites are variant dependent and differ by geographic region

J Doritchamou, A Teo, R Morrison, G Arora… - Infection and …, 2019 - Am Soc Microbiol
… are at high risk of Plasmodium falciparum infection resulting in placental malaria (PM), which
… A vaccine that can induce antibodies with broadly neutralizing activity is key to ensuring its …

VAR2CSA Domain-Specific Analysis of Naturally Acquired Functional Antibodies to Plasmodium falciparum Placental Malaria

JYA Doritchamou, R Herrera, JA Aebig… - The Journal of …, 2016 - academic.oup.com
… the parasites in the placenta [6]. Placental parasites predominantly express a member of
P. … Whether antibody induced by animal immunization with recombinant protein displays a …

P. falciparum infection and maternofetal antibody transfer in malaria-endemic settings of varying transmission

…, C Clapham, F Baiwog, M Pimanpanarak, P Siba… - PloS one, 2017 - journals.plos.org
falciparum infection may also impact maternofetal antibody … through the induction of
pathological changes in the placenta including … in the placenta (pathology class 1–3) to no …

Interaction between endothelial protein C receptor and intercellular adhesion molecule 1 to mediate binding of Plasmodium falciparum-infected erythrocytes to …

M Avril, M Bernabeu, M Benjamin, AJ Brazier, JD Smith - MBio, 2016 - Am Soc Microbiol
… We show that two parasite lines expressing domain cassette 13 (DC13) of the P. … Percent
inhibition is based on parasite binding levels in the absence of antibody treatment. The bar …

VAR2CSA-Mediated Host Defense Evasion of Plasmodium falciparum Infected Erythrocytes in Placental Malaria

A Tomlinson, JP Semblat, B Gamain… - Frontiers in …, 2021 - frontiersin.org
… PAMVAC trials nevertheless revealed that vaccine-induced antibodies had a limited capability
to cross-react with VAR2CSA originating from heterologous parasite strains (133, 134), …

[HTML][HTML] Comparison of functional assays used in the clinical development of a placental malaria vaccine

C Pehrson, KK Heno, Y Adams, M Resende… - Vaccine, 2017 - Elsevier
induced antibodies that inhibited IE adhesion in placental … Infection with Plasmodium
falciparum in pregnancy is … CSA is abundant in the placenta, and parasites bind both to the …