… Cytotoxic CD8 T Cell Priming Using Dendritic Cell–Expressing Human Papillomavirus-16 E6/E7-p16INK4 Fusion Protein with Sequenced Anti–Programmed Death-1

TM Garcia-Bates, E Kim… - The Journal of …, 2016 - journals.aai.org
… a deleterious effect on the induction of specific responses, we measured the activation and
turnover of T cells during the priming (first) phase of stimulation. After 12 d, bulk CD8 + T cells …

… of a rearranged human papillomavirus type 16 E6/E7 fusion protein and Fms-like tyrosine kinase-3 ligand induces CD8+ T cell responses and antitumor effect

J Li, S Chen, J Ge, F Lu, S Ren, Z Zhao, X Pu, X Chen… - Vaccine, 2017 - Elsevier
… The expression level of wild type HPV16 E6/E7 fusion protein … The modified E6/E7 fusion
protein used in this study not only … of the fusion protein, since the antigen-specific CTL immune …

… of DNA vaccine targeting E6 and E7 proteins of human papillomavirus 16 (HPV16) and HPV18 for immunotherapy in combination with recombinant vaccinia boost …

S Peng, L Ferrall, S Gaillard, C Wang, WY Chi… - MBio, 2021 - Am Soc Microbiol
… 16/18 E6/E7-specific CD8 + T cell responses, either alone or in … of HPV 16/18 E6/E7 fusion
proteins by codon optimization in … This effect may be attributed to cytotoxic T lymphocyte (CTL) …

Enhancement of specific T-lymphocyte responses by monocyte-derived dendritic cells pulsed with E2 protein of human papillomavirus 16 and human p16INK4A

N Sunthamala, N Sankla, J Chuerduangphui… - PeerJ, 2020 - peerj.com
response to host p16INK4a and HPV E2 is induced via … Here, we aimed to develop human
p16INK4a and HPV16 E2 … The fusion protein HPV-16 E6/E7 and Fms-like tyrosine kinase-…

[HTML][HTML] Human Papillomavirus Type 16 Based L1, L2, E6, and E7 Peptide Microspheres Induce Encapsulated Peptide Mixture Specific Cytotoxic T Lymphocytes and …

MA Khan, K Ali, M Rizvi - Cancer Screening and Prevention, 2024 - xiahepublishing.com
… C57BL/6 origin with the HPV16 E6/E7 virus and the c-Hras oncogene… calreticulin-human
papillomavirus 16 E7 fusion protein … harboring human papillomavirus 16 cytotoxic T lymphocyte

Microparticles produced by human papillomavirus type 16 E7-expressing cells impair antigen presenting cell function and the cytotoxic T cell response

J Zhang, C Burn, K Young, M Wilson, K Ly… - Scientific reports, 2018 - nature.com
… CaSki cells are HPV16 E6/E7 positive cells derived from … cells that is required for the induction
of CD8 T effector cells with … following their fusion or through internalization by pinocytosis …

Characterization of HPV18 E6-specific T cell responses and establishment of HPV18 E6-expressing tumor model

Y Ma, A Yang, S Peng, J Qiu, E Farmer, CF Hung… - Vaccine, 2017 - Elsevier
… HPV16-E6/E7-expressing murine tumor cell line, TC-1 was … /6 mice, and thus, fusion to ER
localizing protein CRT was … of antigen-specific CD8+ T cells, assisting cytotoxic T-lymphocyte (…

Construction and immune effect of an HPV16/18/58 trivalent therapeutic adenovirus vector vaccine

B Wan, L Qin, W Ma, H Wang - Infectious Agents and Cancer, 2022 - Springer
… and specific cytotoxic T lymphocyte (CTL) and T lymphocytefusion gene and HPV58E6E7
fusion gene into U14 cells … , and the vaccine could induce E7-specific CD8 + T cell immunity …

CUE-101, a novel E7-pHLA-IL2-Fc fusion protein, enhances tumor antigen-specific T-cell activation for the treatment of HPV16-driven malignancies

SN Quayle, N Girgis, DR Thapa, Z Merazga… - Clinical Cancer …, 2020 - AACR
… -specific CD8 + T cells in preclinical studies. In vivo studies confirm selective expansion of
tumor-specific cytotoxic CD8 + T cells, induction … with an E6/E7 vaccination approach resulted …

… enhances vaccine-mediated therapeutic control of human papilloma virus-associated tumors by the activation of multifunctional and effector memory CD8+ T cells

NS Sales, JR Silva, LRMM Aps, MO Silva… - Vaccine, 2017 - Elsevier
fused to the HSV-1 glycoprotein D (gD), that elicits the activation of E7-… responses and
antitumor effects induced by the gD-based DNA vaccine, with particular emphasis on CD8 + T …