… receptor CCR2 contributes to neuropathic pain and the associated depression via increasing NR2B-mediated currents in both D1 and D2 dopamine receptor …

XB Wu, PB Jing, ZJ Zhang, DL Cao, MH Gao… - …, 2018 - nature.com
inflammation is involved in the pathogenesis of both pain … shows that Ccr2 mRNA expression
was increased at days 3, 7, … receptor potentiator delivered into the NAc decreases pain-…

D2-like receptor agonist synergizes the μ-opioid agonist spinal antinociception in nociceptive, inflammatory and neuropathic models of pain in the rat

J Mercado-Reyes, A Almanza, P Segura-Chama… - European Journal of …, 2019 - Elsevier
… Quinpirole (D2-like receptor agonist) increased PWL only in mechanonociception. In the …
antinociceptive effect between opioidergic and dopaminergic drugs. This combination may …

Neuropathic pain dysregulates gene expression of the forebrain opioid and dopamine systems

A Wawrzczak-Bargieła, B Ziółkowska… - Neurotoxicity …, 2020 - Springer
… CCI produced dramatic decreases in pain thresholds in the … the dopamine D1 and D2
receptor mRNA and protein levels … and inflammatory pain models, increased synaptic levels of …

Immunomodulatory effects of dopamine in inflammatory diseases

Y Feng, Y Lu - Frontiers in immunology, 2021 - frontiersin.org
… Besides, D3R expression in Tregs is unaltered in untreated MS patients but significantly
decreases after IFN-β treatment. A recent study showed that increased D3R and D5R mRNA

The distinct functions of dopaminergic receptors on pain modulation: a narrative review

X Wang, T Mokhtari, Y Zeng, L Yue, L Hu - Neural Plasticity, 2021 - Wiley Online Library
… For inflammatory pain induced by carrageenan, IT administration … In addition, mRNA levels
of D2 and D1 receptors both … , which is diminished by the activation of D2 receptors [77]. In …

[PDF][PDF] Increases in Pro-inflammatory Cytokines in the Ventral Striatum Following Frequent Morphine Exposure Impose New Setpoints in the Expression of Biologically …

S Ahmadi, A Khanizad, S Fotouhi - Jentashapir Journal of Cellular …, 2022 - brieflands.com
… in the mRNA levels of mu-opioid receptor, dopamine D1 receptor (… in controlling severe acute
and chronic pain; however, their … the mRNA levels of some of the cell membrane receptors, …

A critical role for dopamine D5 receptors in pain chronicity in male mice

S Megat, S Shiers, JK Moy… - Journal of …, 2018 - Soc Neuroscience
… We show that genetic ablation of the D5R reduces acute pain … Because increased blood flow
in inflammation also changes … females and where these receptor mRNAs were expressed in …

KLF15 regulates dopamine D2 receptor and participates in mouse models of neuropathic pain

J Zhou, F Wang, C Xu, Z Zhou, W Zhang - Biochemical and biophysical …, 2017 - Elsevier
… Our results demonstrated that the mRNA and protein levelsInflammation can be induced
by neuropathic pain insults and … (C)Klf15 knockout reduces the mRNA and protein levels of …

Spinal dopaminergic D1 and D5 receptors contribute to reserpine-induced fibromyalgia-like pain in rats

YE De la Luz-Cuellar, EJ Rodríguez-Palma… - Brain Research, 2023 - Elsevier
… , inflammatory and neuropathic pain. However, the role of … 1 and D 5 receptors reduces
nociception in reserpine-treated … increased Drd5, and at lesser extent Drd1, receptor mRNA

Blockade of neuronal dopamine D2 receptor attenuates morphine tolerance in mice spinal cord

WL Dai, F Xiong, B Yan, ZY Cao, WT Liu, JH Liu… - Scientific reports, 2016 - nature.com
… glias can increase the release of pro-inflammatory cytokines … Unaltered D1, D2, D4, and
D5 dopamine receptor mRNA … in mice with inflammatory pain produce potent antinociception. …