Long-term physical stability of PVP-and PVPVA-amorphous solid dispersions
K Lehmkemper, SO Kyeremateng… - Molecular …, 2017 - ACS Publications
… for the systems acetaminophen/PVPVA64 and naproxen/PVP K25 it is close to the … Influence
of RH on the phase behavior of ASDs: (a) acetaminophen/PVP K25 and (b) naproxen/PVP …
of RH on the phase behavior of ASDs: (a) acetaminophen/PVP K25 and (b) naproxen/PVP …
[HTML][HTML] Effect of storage humidity on physical stability of spray-dried naproxen amorphous solid dispersions with polyvinylpyrrolidone: two fluid nozzle vs. three fluid …
… The ratio of this intensity to the corresponding peak intensity of the naproxen-PVP physical
… composition of the 2FN and 3FN ASD formulations (p > 0.05). The molecular miscibility …
… composition of the 2FN and 3FN ASD formulations (p > 0.05). The molecular miscibility …
Melt extrusion vs. spray drying: The effect of processing methods on crystalline content of naproxen-povidone formulations
… they are thermodynamically miscible. When the material leaves the extruder it cools and the
kinetic stabilization becomes the driving force for physical stability. Additional manufacturing …
kinetic stabilization becomes the driving force for physical stability. Additional manufacturing …
Reactive melt extrusion to improve the dissolution performance and physical stability of naproxen amorphous solid dispersions
… components affects not only the miscibility but also the physical stability of the resulting solid
… used has a great influence on physical stability. NPX–SOLUPLUS ASD showed the poorest …
… used has a great influence on physical stability. NPX–SOLUPLUS ASD showed the poorest …
Physical stability of API/polymer-blend amorphous solid dispersions
K Lehmkemper, SO Kyeremateng, M Bartels… - European Journal of …, 2018 - Elsevier
… One important criterion for the development of ASD compositions is the physical stability. In
… impact of the composition of such API/polymer-blend ASDs on the long-term physical stability …
… impact of the composition of such API/polymer-blend ASDs on the long-term physical stability …
[HTML][HTML] Evaluation of different thermoanalytical methods for the analysis of the stability of naproxen-loaded amorphous solid dispersions
… to the polymer, which can influence the glass transition temperature and also the physical
stability of the ASDs [50]. To exclude the effect of the residual solvents coming from the solvent-…
stability of the ASDs [50]. To exclude the effect of the residual solvents coming from the solvent-…
Analytical and computational methods for the determination of drug-polymer solubility and miscibility
… miscibility is an important contributor to the physical stability … the system during stability
studies can significantly impact the … induced immiscibility for naproxen-PVP K25 ASD using …
studies can significantly impact the … induced immiscibility for naproxen-PVP K25 ASD using …
Spray drying of naproxen and naproxen sodium for improved tableting and dissolution–physicochemical characterization and compression performance
… they are likely to be miscible. The measured melting … stability test (75% RH/40 C) showed
a minor effect on the release and mechanical strength of naproxen sodium and a greater effect …
a minor effect on the release and mechanical strength of naproxen sodium and a greater effect …
Investigating the correlation between miscibility and physical stability of amorphous solid dispersions using fluorescence-based techniques
B Tian, X Tang, LS Taylor - Molecular pharmaceutics, 2016 - ACS Publications
… prepared naproxen–PVP dispersions from different solvents via … in miscibility and in the
corresponding physical stability of the … influence of absorbed moisture, which can impact the …
corresponding physical stability of the … influence of absorbed moisture, which can impact the …
The influence of hydrogen bonding between different crystallization tendency drugs and PVPVA on the stability of amorphous solid dispersions
J Wu, G Van den Mooter - International Journal of Pharmaceutics, 2023 - Elsevier
… to compare the effect of intermolecular hydrogen bonds on the stability of this … stability was
further analyzed by the state diagram. This study clearly pointed out that the physical stability …
further analyzed by the state diagram. This study clearly pointed out that the physical stability …