Long-term physical stability of PVP-and PVPVA-amorphous solid dispersions

K Lehmkemper, SO Kyeremateng… - Molecular …, 2017 - ACS Publications
… for the systems acetaminophen/PVPVA64 and naproxen/PVP K25 it is close to the … Influence
of RH on the phase behavior of ASDs: (a) acetaminophen/PVP K25 and (b) naproxen/PVP

[HTML][HTML] Effect of storage humidity on physical stability of spray-dried naproxen amorphous solid dispersions with polyvinylpyrrolidone: two fluid nozzle vs. three fluid …

SV Bhujbal, Y Su, V Pathak, DY Zemlyanov… - Pharmaceutics, 2021 - mdpi.com
… The ratio of this intensity to the corresponding peak intensity of the naproxen-PVP physical
composition of the 2FN and 3FN ASD formulations (p > 0.05). The molecular miscibility

Melt extrusion vs. spray drying: The effect of processing methods on crystalline content of naproxen-povidone formulations

A Haser, T Cao, J Lubach, T Listro, L Acquarulo… - European Journal of …, 2017 - Elsevier
… they are thermodynamically miscible. When the material leaves the extruder it cools and the
kinetic stabilization becomes the driving force for physical stability. Additional manufacturing …

Reactive melt extrusion to improve the dissolution performance and physical stability of naproxen amorphous solid dispersions

X Liu, L Zhou, F Zhang - Molecular pharmaceutics, 2017 - ACS Publications
… components affects not only the miscibility but also the physical stability of the resulting solid
… used has a great influence on physical stability. NPX–SOLUPLUS ASD showed the poorest …

Physical stability of API/polymer-blend amorphous solid dispersions

K Lehmkemper, SO Kyeremateng, M Bartels… - European Journal of …, 2018 - Elsevier
… One important criterion for the development of ASD compositions is the physical stability. In
impact of the composition of such API/polymer-blend ASDs on the long-term physical stability

[HTML][HTML] Evaluation of different thermoanalytical methods for the analysis of the stability of naproxen-loaded amorphous solid dispersions

E Szabó, A Haraszti, P Záhonyi, D Vadas, I Csontos… - Pharmaceutics, 2022 - mdpi.com
… to the polymer, which can influence the glass transition temperature and also the physical
stability of the ASDs [50]. To exclude the effect of the residual solvents coming from the solvent-…

Analytical and computational methods for the determination of drug-polymer solubility and miscibility

SD Thakore, J Akhtar, R Jain, A Paudel… - Molecular …, 2021 - ACS Publications
miscibility is an important contributor to the physical stability … the system during stability
studies can significantly impact the … induced immiscibility for naproxen-PVP K25 ASD using …

Spray drying of naproxen and naproxen sodium for improved tableting and dissolution–physicochemical characterization and compression performance

N Al-Zoubi, F Odeh, I Partheniadis… - Pharmaceutical …, 2021 - Taylor & Francis
… they are likely to be miscible. The measured melting … stability test (75% RH/40 C) showed
a minor effect on the release and mechanical strength of naproxen sodium and a greater effect

Investigating the correlation between miscibility and physical stability of amorphous solid dispersions using fluorescence-based techniques

B Tian, X Tang, LS Taylor - Molecular pharmaceutics, 2016 - ACS Publications
… prepared naproxenPVP dispersions from different solvents via … in miscibility and in the
corresponding physical stability of the … influence of absorbed moisture, which can impact the …

The influence of hydrogen bonding between different crystallization tendency drugs and PVPVA on the stability of amorphous solid dispersions

J Wu, G Van den Mooter - International Journal of Pharmaceutics, 2023 - Elsevier
… to compare the effect of intermolecular hydrogen bonds on the stability of this … stability was
further analyzed by the state diagram. This study clearly pointed out that the physical stability