… an important role in the development of hematopoietic progenitors. The oncogenic FLT3 …
RAS palmitoylation cycle and its cellular localization, thus suppressing the growth of murine …

… in selective vulnerabilities. Specifically, inhibiting the palmitoylation/depalmitoylation cycle
is an … and overcome density-dependent growth inhibition. These authors also transplanted …

… rate of mitochondrial palmitoylation/depalmitoylation cycles 33 . The … inhibited activation of
the kinase PI3K and reduced tumor … role in the development of melanoma and hematopoietic …

… on a palmitoylation/depalmitoylation cycle to regulate their … MEK inhibition to block
NRAS-mutant cancer cell growth and … -Ras HVR in transduced primary hematopoietic cells 36 . …

… The dynamic cycle of palmitoylation takes seconds to hours … role in the development of
hematopoietic progenitors [148]. … palmitoylated proteins is hindering our understanding of the …

… A growing number of leukocyte proteins have been reported … again and redirected to plasma
membrane for the next cycle. … intracellular palmitate concentration by the inhibition of de …

… or affect hematopoiesis, suggesting that strategies that globally inhibit DHHC9 activity may
not be … Cravatt and colleagues identified inhibitors selective for either APT1 (ML348) or APT2 (…

… , and S-palmitoylated proteins can undergo cycles of palmitoylation and de-palmitoylation …
been proposed to be an NMT1 inhibitor and inhibits growth of melanoma in vitro and in vivo. …

… of mitochondrial palmitoylation/depalmitoylation 265 cycles [33]. … inhibited 302 activation of
the kinase PI3K and reduced … the development of melanoma and hematopoietic malignancies…

… , depend on a palmitoylation/depalmitoylation cycle to regulate … MEK inhibition to block NRAS
mutant cancer cell growth. … -Ras HVR in transduced primary hematopoietic cells 56 . Using …